IL-6基因多态性与心房颤动相关性的Meta分析

Meta Analysis of the Correlation Between IL-6 Gene Polymorphism and Atrial Fibrillation

目的分析IL-6基因多态性与心房颤动发病风险的相关性研究。方法计算机检索万方、知网、维普、PubMed等数据库,检索关于IL-6基因多态性与心房颤动的病例对照研究,检索时间区间均从建库至2019年12月。对于纳入的研究,应用Rev Man5.3软件进行分析。结果共纳入7项研究,Meta分析结果显示,IL-6-572C/G、IL-6-634C/G多态性与心房颤动明显相关(P<0.01),其中IL-6-572C/G基因多态性中,携带GG基因型的个体患者心房颤动的风险是携带CC个体的3.39倍[95%CI(2.18,5.29),P<0.00001],携带GC基因型的个体患者心房颤动的风险是携带CC个体的1.58倍[95%CI(1.30,1.92),P<0.00001];IL-6-634C/G基因多态性中,携带GG基因型的个体患者心房颤动的风险是携带CC个体的5.80倍[95%CI(1.15,29.39),P=0.03]。而IL-6-174G/C、IL-6-597G/A多态性与心房颤动无关。结论IL-6-572C/G基因型GG、GC和IL-6-634C/G基因型GG可能是心房颤动发生的风险基因型。

Objective To study the correlation between IL-6 gene polymorphism and atrial fibrillation risk.Methods The computer searched Wanfang,HowNet,Weipu,PubMed and other databases to search for case-control studies on IL-6 gene polymorphism and atrial fibrillation.The search time interval was from the establishment of the database to December 2019.For the included studies,Rev Man5.3 software was used for analysis.Results A total of 7 studies were included.The results of Meta analysis showed that IL-6-572C/G and IL-6-634C/G polymorphisms were significantly related to atrial fibrillation(P<0.01),among which IL-6-572C/G genes were the morphology,the risk of atrial fibrillation in individuals with GG genotype is 3.39 times that of individuals with CC[95%CI(2.18,5.29),P<0.00001].The risk of atrial fibrillation in individuals with GC genotype is that of carrying 1.58 times that of individuals with CC[95%CI(1.30,1.92),P<0.00001];among IL-6-634C/G gene polymorphisms,the risk of atrial fibrillation in individuals with GG genotype is 5.80 compared with individuals with CC Times[95%CI(1.15,29.39),P=0.03].The IL-6-174G/C and IL-6-597G/A polymorphisms have nothing to do with atrial fibrillation.Conclusion IL-6-572C/G genotype GG,GC and IL-6-634C/G genotype GG may be risk genotypes for atrial fibrillation.