ApoE基因多态性与阿尔茨海默病中医证候的相关性探讨

Correlation between apolipoprotein E gene polymorphism and Alzheimer′s disease syndrome type in traditional Chinese medicine

随着载脂蛋白E(ApoE)基因多态性作用于阿尔茨海默病(AD)发病机制的研究不断深入,且从基因水平对AD中医证候的本质研究得到初步发展,基因多态性和中医证候的相关性逐步得到验证,而从该角度分析疾病的发生发展可为疾病的诊疗提供新的思路。综述近年来ApoE基因多态性在AD发病机制中作用及其与AD中医证候相关性的研究,以期为中医预防和治疗AD提供新的思路和方法,为中医证候分类提供微观依据。

With the deepening of the research on the role of apolipoprotein E gene(ApoE)polymorphism in the pathogenesis of Alzheimer′s disease(AD),and the preliminary development of the study on the nature of traditional Chinese medicine(TCM)syndrome of AD at the gene level,the correlation between gene polymorphism and TCM syndrome has been gradually verified.Analyzing the occurrence and development of the disease from this point of view can provide new ideas for the diagnosis and treatment of the disease.This article reviews the literature on the role of ApoE gene polymorphism in the pathogenesis of AD and its correlation with TCM syndromes of AD in recent years,so as to provide new ideas and intervention methods for TCM prevention and treatment of AD,and may provide micro basis for TCM syndrome classification.