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凝血因子Ⅹa抑制剂阿哌沙班的专利布局及专利技术特点和启示 被引量:2

Patent portfolio,patent technology characteristics ofⅩa inhibitor apixaban and its enlightenment
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摘要 血栓形成是导致心血管疾病的重要病理过程之一,凝血因子Ⅹa抑制剂是一类新型的抗凝血药物,具有可口服、无需监测、出血不良反应小等优点。阿哌沙班作为此类药物的代表,在临床上应用广泛,效果良好。本文选取此类药物中具有代表性的阿哌沙班,对其相关专利申请状况进行了分析,并重点对专利技术发展路线进行了介绍,还对重要申请人的专利申请发展路线进行了梳理,以期为国内研发机构和相关企业对于阿哌沙班的后期开发、专利保护策略以及知识产权布局提供有益的参考和建议。 Thrombosis is one of the important pathological processes leading to cardiovascular diseases.Coagulation factor Xa inhibitors are a class of novel anticoagulant drugs with the advantages of oral administration,no need for monitoring and low bleeding adverse reactions.As a representative of this kind of drugs,apixaban is widely used in clinical practice and has good effect.In this pa⁃per,we analyze the patent application status,introduce the patent technology development route of apixaban in detail,and sort out the development route of patent application of important applicants,to provide useful reference and suggestions for domestic research insti⁃tutions and related enterprises on the later development,patent protection strategy and intellectual property layout of apixaban.
作者 陈峰 高昶 CHEN Feng;GAO Chang(Patent Examination Cooperation Jiangsu Center of the Patent Office,CNIPA,Suzhou 215163,China)
出处 《国际药学研究杂志》 CAS 北大核心 2020年第9期709-715,721,共8页 Journal of International Pharmaceutical Research
关键词 阿哌沙班 专利分析 专利布局 apixaban patent analysis patent portfolio
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