T细胞及其表位在食物过敏中的研究进展

Research Progress in T Cells and Their Epitopes in Food Allergy

食物过敏蛋白经胃肠道消化后经树突状细胞递呈给T细胞后,会启动过敏反应的发生。在此过程中,不同T细胞发挥了不同的作用,其中Th1/Th2下调被认为是引发过敏反应的主要工作机制,Th9、Th17和Tfh等细胞在过敏反应发展中的作用不容忽视。作者介绍了不同T淋巴细胞的作用,探讨了T细胞表位预测及定位以及目前T细胞表位在常见过敏原蛋白中的应用,综述了T细胞在食物过敏中的研究进展。

The allergy peptides from food protein digested by gastrointestinal tract were presented by dendritic cell to T cells,which led to allergic reaction.T cells could differentiate into certain subgroups and play different roles in immune reaction.Among them,the down-regulation of Th1/Th2 was considered as a trigger of the hypersensitivity reaction such as food allergy.The role of Th9,Th17,Tfh and other Th cells cannot be ignored in the development of allergic reactions.Therefore,this review comprehensively summarized the research of T cells on food allergy,introducing the roles of T lymphocytes with different subgroup,prediction and mapping of T cell epitopes in common allergen proteins,and the application of T cell epitopes,etc.