重组人生长激素治疗生长激素缺乏症儿童的临床效果

Clinical effect of recombinant human growth hormone on children with growth hormone deficiency

目的观察重组人生长激素(rhGH)治疗生长激素缺乏症(GHD)儿童的临床效果。方法选取2017年7月至2018年7月我院儿童保健科门诊收治的120例GHD患儿为研究对象,所有患儿均采用国产rhGH持续治疗12个月。比较治疗前后患儿的生长指标、IGF-1、IGFBP-3、IGF-1/IGFBP-3及甲状腺功能指标水平。结果治疗6个月及1年,患儿的身高、生长速率较治疗前显著提升(P<0.05)。治疗时间每延长3个月,患儿的身高和生长速率呈明显下降的趋势,0~3个月的治疗效果最佳。治疗3、6、9个月和1年时患儿的IGF-1、IGFBP-3水平和IGF-1/IGFBP-3均依次升高,且均显著高于治疗前(P<0.05)。治疗3、6、9个月和1年时患儿的FT3水平较治疗前显著升高(P<0.05)。结论 rhGH应用于GHD儿童治疗中,能够促进患儿身高和生长速率的提升,有效改善患儿IGF-1、IGFBP-3水平和IGF-1/IGFBP-3,具有显著的促生长发育效果,且0~3个月的治疗效果最佳。

Objective To observe the clinical effect of recombinant human growth hormone(rhGH)on children with growth hormone deficiency(GHD).Methods One hundred and twenty children with GHD admitted in the outpatient service of children's health care department of our hospital from July 2017 to July 2018 were selected as the study objects.All children were treated with domestic rhGH for 12 months.The growth indexes,IGF-1,IGFBP-3,IGF-1/IGFBP-3 and thyroid function indexes levels were compared before and after treatment.Results The height and growth rate of the children at 6 months and 1 year of treatment were significantly higher than those before treatment(P<0.05).Every 3 months of treatment,the height and growth rate of the children showed a significant downward trend,and the treatment effect of 0-3 months was the best.The levels of IGF-1,IGFBP-3 and IGF-1/IGFBP-3 increased in turn at 3,6,9 months and 1 year of treatment,and the levels of above indicators after treatment were significantly higher than those before treatment(P<0.05).The level of FT3 at 3,6,9 months and 1 year of treatment were significantly higher than those before treatment(P<0.05).Conclusion RhGH can promote the height and growth rate of children with GHD,and improve the levels of IGF-1,IGFBP-3 and IGF-1/IGFBP-3 effectively,with significant effect of promoting growth and development,and the treatment effect of 0-3 months is the best.