血清AMH与性激素、抑制素B联合检测对多囊卵巢综合征的辅助诊断应用

Application of combined detection of serum AMH,sex hormones and inhibin B in diagnosis of polycystic ovary syndrome

目的:分析血清抗缪勒管激素(AMH)与性激素、抑制素B联合检测对多囊卵巢综合征的辅助诊断价值。方法:将我院2018年1月至2020年1月收治的180例多囊卵巢综合征患者作为研究组,选择同时间段内180例行健康体检作为参照组,两组患者均接受血清AMH、性激素以及抑制素B检测,比较两组患者的检测结果,分析两组血清AMH水平与年龄以及性激素指标间的相关性,观察单独检测与联合检测对多囊卵巢综合征的诊断价值。结果:研究组生化指标明显优于参照组(P<0.05)。研究组血清AMH与性激素指标呈正相关关系(P<0.05),与年龄无相关性(P>0.05);对照组血清AMH与年龄呈负相关关系(P<0.05),与性激素指标无相关性(P>0.05)。三项联合检测的敏感度与特异度分别为95.56%、96.67%。结论:多囊卵巢综合征患者采用血清AMH、性激素联合抑制素B检测的敏感度与特异度较高,可加大临床推广力度。

Objective:To analyze the auxilliary diagnostic value of combined detection of serum anti-Mullerian hormone(AMH)with sex hormones and inhibin B for polycystic ovary syndrome.Methods:180 patients with multiple ovarian syndrome treated in our hospital from January 2018 to January 2020 were selected as the study group,and 180 healthy medical examinations were selected as the reference group in the same period of time.Both patients received the detection of serum AMH,sex hormones and inhibin B.The test results of the two groups of patients were compared,and the correlation between serum AMH levels and age and sex hormone indicators in the two groups was analyzed,and the diagnostic value of single detection and combined detection for polycystic ovary syndrome was observed.Results:The biochemical indexes of the study group were significantly better than those of the reference group(P<0.05).There was a positive correlation between serum AMH and sex hormone indicators in the study group(P<0.05)and no correlation with age(P>0.05);a negative correlation between serum AMH and age in the control group(P<0.05),and no correlation with sex hormone indicators(P>0.05).The sensitivity and specificity of the three joint tests were 95.56%and 96.67%respectively.Conclusion:The sensitivity and specificity of serum AMH and sex hormone combined inhibin B detection in patients with polycystic ovary syndrome are higher,which can increase clinical promotion.