舍曲林联合正念认知疗法对抑郁症患者认知功能及生活质量的影响

Effect of sertraline combined with mindfulness cognitive therapy on cognitive function and quality of life in patients with depression

目的:探讨舍曲林联合正念认知疗法对抑郁症患者认知功能及生活质量的影响。方法:选取2018年6月至2020年4月本院诊治的90例抑郁症患者分为观察组和对照组,观察组给予舍曲林联合正念认知疗法治疗,对照组给予舍曲林治疗,比较两组临床疗效、治疗前后精神和生活质量相关量表评分(HAMD量表、WHOQOL-BREF量表、RBANS量表)。结果:观察组临床疗效总有效率为91.11%,较对照组的75.56%显著提高(P<0.05),治疗前两组HAMD量表评分、WHOQOL-BREF量表评分及RBANS量表各维度评分无显著性差异(P>0.05);治疗8周后观察组HAMD量表评分明显下降,WHOQOL-BREF量表及RBANS量表各维度评分明显提高,与对照组的变化比较差异显著(P<0.05)。结论:舍曲林联合正念认知疗法治疗抑郁症患者可提高临床疗效,改善患者抑郁症状,促进认知功能和生活质量的提高,值得推广。

Objective:To explore and analyze the effect of sertraline combined with mindfulness cognitive therapy on cognitive function and quality of life in patients with depression.Methods:Ninety patients with depression admitted to our hospital from June 2018 to April 2020 were divided into observation group and control group.The observation group was treated with sertraline combined with mindfulness cognitive therapy,and the control group was treated with sertraline only.The clinical efficacy,mental and quality of life related scale scores(HAMD scale,WHOQOL-BREF scale,RBANS scale)were compared between the two groups before and after treatment.Results:The total clinical efficacy rate of the observation group was 91.11%,which was significantly higher than 75.56%in the control group’s(P<0.05).There was no significant difference in the scores of the HAMD scale,WHOQOL-BREF scale and RBANS scale between the two groups before treatment(P>0.05).After 8 weeks of treatment the HAMD scale of the observation group decreased significantly and the WHOQOL-BREF scale and RBANS scale increased more significantly(P<0.05).Conclusion:Sertraline combined with mindfulness cognitive therapy can improve the clinical efficacy,improve the symptoms of depression,and promote the improvement of cognitive function and quality of life in the treatment of depression.It is worthy of promotion.