不同来源的间充质干细胞在肝病中的治疗作用

Therapeutic effect of mesenchymal stem cells from different sources in the treatment of liver diseases

乙型肝炎病毒(hepatitis B virus,HBV)仍是威胁人类生命健康安全的重要问题之一,若不能有效控制病毒,则会逐渐演变成慢性肝炎。慢性肝炎经久不治,将逐步往肝纤维化、肝硬化、肝癌甚至肝衰竭等预后较差的疾病发展,而针对肝纤维化、肝硬化等疾病,暂无特效西药治疗,临床常以对症治疗、内科综合治疗、预防并发症等治疗手段为主。近年来,医疗技术得到不断发展和提升,国内外学者潜心研究防治肝脏疾病的有效途径,越来越多的研究证实间充质干细胞(mesenchymal stem cell,MSC)在治疗肝脏疾病上发挥了重要作用,笔者将针对不同来源的间充质干细胞对肝脏疾病的治疗作用作统一叙述。

Hepatitis B Virus(HBV)is still one of the severe problems threatening the health and safety of human life.If the virus cannot be effectively controlled,it will gradually evolve into chronic hepatitis.Chronic hepatitis is difficult to be cured,and will gradually develop into liver fibrosis,cirrhosis,liver cancer or even liver failure and other diseases with poor prognosis.However,there is no specific western medicine treatment for liver fibrosis,cirrhosis and other liver diseases.The main treatment methods are symptomatic treatment,internal medicine comprehensive treatment and prevention of complications.In recent years,the medical technology has been continuously developed and improved,scholars at home and abroad have focused on the effective ways to prevent and treat liver diseases.More and more studies have confirmed that the mesenchymal stem cells Cell(MSC)plays an important role in the treatment of liver diseases.This study describes the therapeutic effect of MSC from different sources on liver diseases.