肿瘤相关巨噬细胞在胰腺癌中的研究进展

Progress of tumor-associated macrophages in pancreatic cancer

胰腺癌是消化系统极具侵袭性的恶性肿瘤。其中局部肿瘤的治疗方式主要是手术切除,但适应证过于苛刻。对于晚期胰腺癌,化疗是标准疗法,但患者副作用严重且会产生耐药性。胰腺癌肿瘤微环境中的肿瘤相关巨噬细胞是含量最高的免疫细胞,在肿瘤发展和化学耐药中起着非常重要的作用。抗肿瘤相关巨噬细胞治疗显示出一定的治疗潜力。因此本文对肿瘤相关巨噬细胞在胰腺癌中的作用机制及肿瘤相关巨噬细胞靶向治疗的研究进展作一综述。

Pancreatic cancer is a highly aggressive malignant tumor of the digestive system.Surgical resection is the main treatment of local tumors,but the indications are too strict.For advanced pancreatic cancer,chemotherapy is the standard treatment,but patients have severe side effects and develop drug resistance.Tumor-associated macrophages in the tumor microenvironment of pancreatic cancer are the most abundant immune cells and play a very important role in tumor development and chemoresistance.Antitumor-associated macrophage therapy has shown some therapeutic potential.Therefore,this article reviews the role of tumor-associated macrophages in the pathogenesis of pancreatic cancer and the mechanism of tumor-associated macrophage targeted therapy.