防治内毒素休克凝血功能紊乱的研究进展

Advances in prevention and treatment drug therapy for coagulation disorders during endotoxin shock

凝血功能紊乱是内毒素休克发生微循环障碍、发展至脓毒症的一个关键环节,与患者的器官损伤、死亡率密切相关。针对"降低血液高凝、补充凝血因子、抑制纤溶系统亢进"三个层面,探索有利于恢复机体凝血稳态的相应防治措施,从而改善内毒素休克或脓毒症的预后、降低病死率。

Coagulation disorders are a key link in the process of endotoxic shock-induced microcirculation dysfunction and sepsis,which is closely related to organ injury and mortality of patients.Based on the three aspects of"reducing blood hypercoagulability,supplementing coagulation factors,and inhibiting fibrinolytic hyperactivity",this paper reviews the beneficial effects of preventive and therapeutic measures to restore coagulation homeostasis and improve the prognosis and reduce the mortality of endotoxin shock or sepsis.