小儿手足口病免疫球蛋白和超敏C反应蛋白的临床检验研究

Clinical study of immunoglobulin and hypersensitive C-reactive protein in children with Hand foot and mouth disease

目的研究小儿手足口病免疫球蛋白和超敏C反应蛋白的临床检验。方法样本选取时间2018年2月至2019年8月;样本构成本院收治的22例小儿手足口病(研究组)与22例健康体检患儿(对照组)。对比两组患儿免疫球蛋白A型、免疫球蛋白G型、免疫球蛋白M型、超敏C反应;T淋巴细胞亚群水平(CD3+、CD4+、CD8+)。结果研究组患儿IgA(0.57±0.55)、IgG水平(8.97±4.52)低于对照组的(1.23±0.41、14.62±4.22)(P<0.05);IgM(2.88±0.62)、hs-CRP(10.47±7.98)高于对照组的(1.99±0.25、1.89±1.46)(P<0.05)。研究组患儿急性期与恢复期CD3+、CD4+水平低于对照组(P<0.05)。患儿恢复期CD3+水平高于急性期水平(P<0.05)。研究组患儿急性期、恢复期及对照组CD8+水平无明显差异(P>0.05)。结论小儿手足口病对免疫球蛋白、超敏C反应检验准确,及时确诊病情,对后续治疗具有协同效果,亟待在临床检验中应用。

Objective:To study the clinical test of immunoglobulin and hypersensitive C-reactive protein in children with hand foot and mouth disease.Methods:Sample selection time:From February 2018 to August 2019;Sample composition:22 cases of hand,foot and mouth disease(study group)and 22 cases of healthy children(control group)admitted to our hospital.Immunoglobulin A type,immunoglobulin G type,immunoglobulin M type and hypersensitive C reaction were compared between the two groups.T lymphocyte subsets(CD3+,CD4+,CD8+).Results:The IgA(0.57±0.55)and IgG(8.97±4.52)levels in the study group were lower than those in the control group(1.23±0.41,14.62±4.22)(P<0.05);IgM(2.88±0.62)and HS-CRP(10.47±7.98)were higher than control group(1.99±0.25,1.89±1.46)(P<0.05).The levels of CD3+and CD4+in acute phase and convalescent phase were lower in the study group than in the control group(P<0.05).The level of CD3+in the convalescent stage was higher than that in the acute stage(P<0.05).There was no difference in CD8+levels between the acute stage,recovery stage and control group(P>0.05).Conclusion:HFMD is accurate to immunoglobulin and hypersensitive C reaction tests,timely diagnosis of the disease,and has a synergistic effect on subsequent treatment,and urgently needs to be applied in clinical tests.