复方苦参注射液对肝癌破裂出血行介入栓塞治疗疗效的影响

Effect Study of Compound Kushen Injection after Interventional Embolization for Liver Cancer Patients with Spontaneous Rupture and Bleeding

目的:探讨复方苦参注射液对肝癌破裂出血行介入栓塞治疗疗效及生存率的影响。方法:选取2017年1月~2019年1月本院临床诊断为"肝癌破裂出血"的81例患者,根据治疗方法不同分为治疗组41例与对照组40例。两组均行介入栓塞治疗,对照组术后予以对症治疗,治疗组在对照组基础上予以复方苦参注射液治疗。对比两组术后使用止痛药及止吐药次数、疼痛程度、不良反应发生率、肿瘤再出血率以及甲胎蛋白(AFP)下降率。随访统计两组患者术后1年生存率。结果:治疗组患者术后使用止痛药及止吐药次数少于对照组,且术后6~24 h视觉模拟评分(VAS)低于对照组,有统计学差异(P <0. 05);两组胃肠道反应对比无统计学差异(P> 0. 05);但治疗组术后骨髓抑制率及肝功能损害率低于对照组,有统计学差异(P <0. 05);治疗组肿瘤再出血率低于对照组,AFP下降率高于对照组,有统计学差异(P <0. 05);两组术后1个月的生存率对比无统计学差异(P> 0. 05);治疗组术后3个月和术后1年的生存率高于对照组,有统计学差异(P <0. 05)。结论:使用复方苦参注射液可有效提高肝癌破裂出血介入栓塞的治疗效果,减轻术后疼痛,保护肝功能,改善预后。

Objective:To discuss the effects of Compound Kushen Injection on the survival rate of patients underwent interventional embolization for liver cancer with spontaneous rupture and bleeding.Methods:81 liver cancer patients diagnosed with spontaneous rupture and bleeding from January 2017 to January 2019 were assigned to treatment group(41 cases)and control group(40 cases).All patients underwent interventional embolization.The control group was provided with symptomatic treatment,while treatment group was given additional Compound Kushen Injection on that basis.Medication frequency of analgesic and antemetic drugs,pain degree,adverse reactions,tumor re-bleeding rate,descent rate of alpha fetoprotein(AFP)were recorded;survival rate after 1 year of follow-up visit were counted.Results:Medication frequency of analgesic and antemetic drugs in the treatment group was lower than that of the control group;after 6~24 h of surgery,visual analogue scale(VAS)scores were lower than control group(P<0.05);gastrointestinal reactions was not significant different bwtween groups(P>0.05);after treatment,bone marrow suppression and liver function impairment rate in the treatment group was significantly lower than those of the control group(P<0.05);tumor re-bleeding rate in the treatment group was lower than that of the control group;descent rate of AFP was higher than control group(P<0.05);after 1 month,survival rate between groups showed no significant difference(P>0.05);3 months and 1 year after operation,the survival rate in the treatment group was significantly higher than that of the control group(P<0.05).Conclusion:Compound Kushen Injection can remarkably improve the efficacy of interventional embolization on liver cancer patients with spontaneous rupture and bleeding,relieve pain,protect the liver function and improve the treatment prognosis.