胸腺肽α1在肾病综合征中的应用及研究进展

Application and research progress of thymosinα1 in nephrotic syndrome

肾病综合征是较常见的慢性肾脏病,其并发症或反复复发可导致疾病迁延进展,从而对患者造成更多的精神心理和经济负担。目前认为免疫功能失衡与肾病综合征的发病密切相关。胸腺肽α1作为免疫调节剂,具有改善机体免疫功能、抗氧化、抗炎等作用,在临床上越来越受重视并且在肿瘤及感染等疾病中已经广泛应用于临床,但在肾病综合征中的作用效果仍有待进一步探究。胸腺肽α1的免疫调节疗法或可能成为新的治疗方法应用于肾病综合征。因此,本文将对胸腺肽α1在肾病综合征中的潜在作用机制及临床价值进行综述。

Nephrotic syndrome is a more common chronic kidney disease,and its complications or repeated recurrence can lead to the progression of the disease,thus causing more mental,psychological and economic burden to patients.As an immunomodulator,thymosinα1 has the effects of improving immune function,anti-oxidation,anti-inflammation and so on.It has been paid more and more attention in clinic and has been widely used in diseases such as tumor and infection.However,the effect of thymosinα1 on nephrotic syndrome remains to be further explored.Thymosinα1 immunomodulatory therapy may become a new treatment for nephrotic syndrome.Therefore,this article will review the potential mechanism and clinical value of thymosinα1 in nephrotic syndrome.