补中益气汤对晚期胃癌患者癌因性疲乏及生存质量的影响

Effect of Buzhong Yiqi Decoction on cancer-related fatigue and quality of life in patients with advanced gastric cancer

目的分析补中益气汤对晚期胃癌患者癌因性疲乏及生存质量的影响。方法选取该院2017年12月至2019年12月住院治疗的92例晚期胃癌患者作为研究对象,按照随机数字表法分为参照组和试验组,各46例。参照组给予常规化疗治疗,试验组从化疗第1天起给予补中益气汤治疗,两组消化道不适发生率、Piper疲劳修订量表(RPFS)评分、欧洲癌症研究和治疗组织生存质量核心量表(QLQ-30)评分进行比较分析。结果试验组消化道不适发生率明显比参照组低,差异有统计学意义(P<0.05);试验组治疗2个疗程后RPFS评分低于参照组,差异有统计学意义(P<0.05);试验组治疗2个疗程后QLQ-30评分比参照组高,差异有统计学意义(P<0.05)。结论晚期胃癌患者化疗期间给予补中益气汤治疗,消化道不适症状明显好转,有效缓解了癌因性疲乏,提高患者生存质量,临床疗效显著,值得临床推广。

Objective To analyze the effect of Buzhong Yiqi Decoction on cancer-related fatigue and quality of life in patients with advanced gastric cancer.Methods A total of 92 patients with advanced gastric cancer hospitalized in the hospital from December 2017 to December 2019 were selected as the study subjects.According to the random number table method,they were divided into the reference group and the experimental group,with 46 cases each.The control group was given conventional chemotherapy,while the experimental group was given Buzhong Yiqi Decoction from the first day of chemotherapy.The incidence of gastrointestinal discomfort,Revised Piper Fatigue Scale(RPFS)score and European Organisation for Research and Treatment of Cancer(EORTC)Quality of Life(QLQ-30)score of the two groups were compared and analyzed.Results The incidence of gastrointestinal discomfort in the experimental group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).After two courses of treatment,RPFS score of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).After two courses of treatment,QLQ-30 score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of patients with advanced gastric cancer with Buzhong Yiqi Decoction during chemotherapy has significantly improved the symptoms of gastrointestinal discomfort,effectively alleviated the cancer-related fatigue,and improved the quality of life of the patients.The clinical effect is significant and worthy of clinical promotion.