趋化因子配体16在非小细胞肺癌中的表达

Expression of CXCL16 in non-small cell lung cancer

目的:探讨趋化因子配体16(CXCL16)在NSCLC(NSCLC)中的表达,及对NSCLC的应用价值。方法:检测CXCL16在肺癌细胞系、组织和血清中的表达,分析其表达与临床参数指标的相关性。结果:人肺腺癌细胞株(A549、H1299、H460、H446)中CXCL16表达均高于人正常肺上皮细胞株(B2B细胞)(P<0.05);NSCLC组织中CXCL16表达(84.0%)高于癌旁组织(44.0%),差异有统计学意义(P<0.05);NSCLC患者组血清CXCL16表达水平(1761.28±323.58)pg/mL高于健康对照组(1035.25±201.26)pg/mL(P<0.05)。结论:CXCL16在NSCLC肺腺癌细胞株、组织和血清中均有高表达,提示CXCL16的表达与NSCLC的发生发展可能有一定关系,有望成为NSCLC预测的新指标。

Objective:To investigate the expression of C-X-C chemokine ligand 16(CXCL16)in non-small cell lung cancer NSCLC and its implications in diagnosis of this neoplasm.Methods:CXCL16 expression was measured in lung cancer cell lines,adjacent caner tissues and sera in patients with NSCLC,and analyzed for the correlation with clinical parameters.Results:CXCL16 expression in human lung adenocarcinoma cell lines(A549,H1299,H460 and H446)was significantly higher than that in normal human lung epithelial cell lines(B2B cells)(P<0.05),and CXCL16 was highly expressed in NSCLC tissues compared to the adjacent tissues(84.0%vs.44.0%,P<0.055).Serum CXCL16 level was also higher in NSCLC patients than in subjects in the control group(1761.28±323.58 vs.1035.25±201.26,P<0.05).Conclusion:CXCL16 is highly expressed in lung adenocarcinoma cell lines,NSCLC tissues and serum of NSCLC patients,suggesting that CXCL16 expression may be related to the occurrence and development of NSCLC,and be a new predictor in diagnosis of non-small cell lung cancer.