针灸对轴突生长导向分子影响的研究进展

Research progress of acupuncture and moxibustion on axon guidance cues

轴突生长导向分子有Slit、Semaphorin、Ephrin和Netrin。它们具有调节轴突再生和引导再生轴突向正确靶向延伸的作用,可影响神经系统、心血管系统,参与肿瘤细胞的增殖和迁移等。目前关于针灸(主要集中在电针)对轴突生长导向分子影响的研究仅为动物实验研究。电针可通过调节轴突生长导向分子的表达来治疗以神经系统为主的疾病。本文归纳了针灸调节轴突生长导向分子的研究进展,以期为针灸治疗与轴突生长导向分子相关的疾病提供思路。

Axon guidance cues includes Slit,Semaphorin,Ephrin and Netrin.They have the function of regulating the regeneration of axons and guiding the regenerated axons to the correct target.They can affect the nervous system,cardiovascular system,and participate in the proliferation and migration of tumor cells.The current research on the influence of acupuncture and moxibustion(mainly focusing on electroacupuncture)on axon guidance cues is limited to animal experiments.Electroacupuncture can treat diseases dominated by the nervous system by regulating the expression of axon guidance cues.This review summarizes the research progress of acupuncture and moxibustion on regulating axonal guidance cues,is hoped to provide references for the mechanism of acupuncture and moxibustion in treating nervous system disease and ideas for acupuncture treatment of diseases related to axon guidance cues.