帕瑞昔布钠超前镇痛在宫腔镜检查术中的应用

Application of parecoxib sodium preemptive analgesia in hysteroscopic surgery

目的:观察帕瑞昔布钠超前镇痛在宫腔镜检查术中的应用效果。方法:选择行宫腔镜检查术的患者60例,随机分为超前镇痛组和对照组,每组30例。测定术后0.5 h、1 h、6 h和24 h的视觉模拟评分(visual analogue scale,VAS),并记录术中不良反应发生情况以及医患对镇痛的总体满意度。结果:超前镇痛组术后0.5 h、1 h和6 h的VAS评分均明显低于对照组同一时间点(P<0.05),但术后24 h VAS评分比较,差异无统计学意义(P>0.05)。对照组术后1 h的VAS评分明显高于术后0.5 h(P<0.05),但术后6 h与术后0.5 h评分比较,差异无统计学意义(P>0.05)。超前镇痛组术中体动发生率低于对照组(3.3%vs 20.0%),术者满意度高于对照组(96.7%vs 76.7%),差异均有统计学意义(P<0.05)。结论:帕瑞昔布钠超前镇痛可以显著降低术中体动发生率,减少对术程的干扰,提升患者的镇痛满意度,且安全有效。

Objective:To study the application effect of parecoxib sodium preemptive analgesia in hysteroscopic surgery.Methods:Sixty patients underwent hysteroscopic surgery were randomly divided into the preemptive analgesia group and the control group,30 cases in each group,respectively.The visual analogue scale(VAS)was used to analyze the pain degree at 0.5 h,1 h,6 h and 24 h after operation.The adverse reaction and the overall analgesia satisfaction were recorded.Results:The VAS score in the preemptive analgesia group were significantly lower than those in the control group at 0.5 h,1 h and 6 h after operation(P<0.05),but no significant difference was found at 24 h(P>0.05).In the control group,the VAS score at 1 h after operation was statistically higher than that at 0.5 h after operation(P<0.05),and no significant difference was found between that at 6 h and 0.5 h after operation(P>0.05).The incidence of intraoperative movement in the preemptive analgesia group was lower than that in the control group(3.3%vs 20.0%),the satisfaction of surgeons in the preemptive analgesia group was significantly higher than that in the control group(96.7%vs 76.7%),and the difference was statistically significant(P<0.05).Conclusion:The parecoxib sodium preemptive analgesia is safe and effective method to decrease the rate of body movement during the operation and increase the satisfaction of preemptive analgesia.