c-Met与GPC1在非小细胞肺癌中的表达及预后意义

Expression of c-Met and glypican1 in non-small-cell lung cancer and its prognostic signifi cance

目的探究肝细胞生长因子受体(hepatocyte growth factor receptor,c-Met)与磷脂酰肌醇蛋白聚糖1(glypican 1,GPC1)在非小细胞肺癌(non-small-cell lung cancer,NSCLC)组织中的表达及临床意义。方法收集234例NSCLC患者的肿瘤组织和癌旁组织,免疫组织化学法检测组织中c-Met和GPC1的表达,并分析与患者临床病理资料之间的关系,对全部患者进行预后随访。结果c-Met和GPC1在NSCLC组织中的阳性表达率均高于其癌旁组织(均P<0.05)。两者在NSCLC组织中的表达呈正相关(r=0.706,P<0.01)。c-Met和GPC1在NSCLC组织中的阳性表达在NSCLC患者的临床分期和淋巴结转移方面比较,差异均具有统计学意义(均P<0.05)。c-Met阳性和GPC1阳性患者的5年生存率均低于阴性患者(12.6%vs 56.3%,P<0.05;5.3%vs 28.5%,P<0.05)。c-Met阳性表达、GPC1阳性表达、NSCLC临床分期以及淋巴结转移是NSCLC患者生存时间的主要影响因素(均P<0.01)。结论NSCLC患者肿瘤组织中c-Met和GPC1高表达。c-Met和GPC1阳性表达患者预后不良。

Objective To investigate the expressions of hepatocyte growth factor receptor(c-Met)and glypican 1(GPC1)in non-small-cell lung cancer(NSCLC)and its clinical significance.Methods The expressions of c-Met and GPC1 in 234 NSCLC patients were detected by immunohistochemistry,and the relationship between the expressions of c-Met and GPC1 and clinicopathological data was analyzed.Results The positive expression rates of c-Met and GPC1 in NSCLC tissues were higher than those in adjacent tissues(both P<0.05).The expressions of c-Met and GPC1 were positively correlated in NSCLC tissues(r=0.706,P<0.01).The positive expression rates of c-Met and GPC1 in NSCLC tissues were significantly different in terms of clinical stage and lymph node metastasis(all P<0.05).The 5-year survival rates of c-Met positive and GPC1 positive patients were both lower than those of negative patients(12.6%vs 56.3%,P<0.05;5.3%vs 28.5%,P<0.05).The positive expressions of c-Met and GPC1,clinical stage of NSCLC and lymph node metastasis were the risk factors affecting the survival time of NSCLC patients(all P<0.01).Conclusions c-Met and GPC1 are highly expressed in NSCLC.NSCLC patients with positive expressions of c-Met and GPC1 have poor prognosis.