盐酸米诺环素治疗绝经妇女牙周炎患者的疗效及其对龈沟液中炎性因子和骨代谢因子的影响

Effect of minocycline hydrochloride on periodontitis in postmenopausal women and its influence in inflammatory and bone metabolism factors in gingival crevicular fluid

目的:探讨盐酸米诺环素对绝经妇女牙周炎患者的治疗效果及其对龈沟液中炎性因子与骨代谢因子水平的影响,阐明其在绝经妇女牙周炎患者治疗中的可能作用机制。方法:86例绝经牙周炎女性患者按照患者意愿分为盐酸米诺环素组(观察组,n=43)和碘甘油组(对照组,n=43)。评价2组患者治疗的总有效率,记录并比较治疗前和治疗4周后2组患者的牙周探诊深度(PD)、菌斑指数(PLI)和出血指数(BI)。在治疗前和治疗4周后分别取2组患者的龈沟液,采用酶联免疫吸附试验(ELISA)法检测2组患者龈沟液中炎性因子白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)水平,采用电化学发光法检测2组患者龈沟液中骨代谢因子骨钙素(OC)水平。结果:治疗前2组患者的PD、PLI、BI和龈沟液中IL-6、hs-CRP、TNF-α及OC水平比较差异无统计学意义(P>0.05)。治疗4周后,2组患者的PD、PLI、BI和龈沟液中IL-6、hs-CRP、TNF-α及OC水平均较治疗前明显降低(P<0.05)。与对照组比较,观察组患者总有效率明显升高(P<0.05),PD、PLI和BI明显降低(P<0.05),龈沟液中IL-6、hs-CRP和TNF-α水平均明显降低(P<0.05),龈沟液中OC水平明显降低(P<0.05)。结论:盐酸米诺环素治疗绝经妇女牙周炎患者的疗效显著,可改善患者牙周参数。

Objective:To investigate the therapeutic effect of minocycline hydrochloride in the postmenopausal women with periodontitis and its influence in the levels of inflammatory and bone metabolism factors in the gingival crevicular fluid,and to clarify the possible mechanism of minocycline hydrochloride in the treatment of postmenopausal women with periodontitis.Methods:According to the patients’willing,eighty-six postmenopausal women with periodontitis were divided into minocycline hydrochloride group(observation group,n=43)and iodine glycerin group(control group,n=43).The total effective rates of the patients in two groups were evaluated.The probing depth(PD),plaque index(PLI),and bleeding index(BI)of the patients in two groups were recorded and compared before treatment and 4 weeks after treatment.The levels of interleukin 6(IL-6),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in gingival crevicular fluid of the patients in two groups before treatment and 4 weeks after treatment were measured by ELISA method and the levels of osteocalcin(OC)in gingival crevicular fluid of the patients in two groups were measured by electrochemiluminescence.Results:There were no significant differences in PD,PLI,BI and the levels of IL-6,hs-CRP,TNF-αand OC in gingival crevicular fluid of the patients in two groups before treatment(P>0.05).Four weeks after treatment,PD,PLI,BI and the levels of IL-6,hs-CRP,TNF-αand OC in gingival crevicular fluid of the patients in two groups were significantly lower than those before treatment(P<0.05);compared with control group,the total effective rate of the patients in observation group was significantly increased(P<0.05),PD,PLI and BI were significantly decreased(P<0.05),the levels of IL-6,hs-CRP,and TNF-αin gingival crevicular fluid were significantly decreased(P<0.05),and the level of OC in gingival crevicular fluid decreased was significantly decreased(P<0.05).Conclusion:Minocycline hydrochloride has a significant effect on the treatment of postmenopausal women with periodontitis.It can improve the periodontal parameters.