阿司匹林加替格瑞洛治疗急性心肌梗死的效果

Efficacy of Aspirin Gatigrillo in the Treatment of Acute Myocardial Infarction

目的观察替格瑞洛加阿司匹林对急性心肌梗死的联合治疗效果。方法抽选2018年1月—2019年12月期间于该院被确诊为急性心肌梗死的50例患者,回顾分析其基本资料,以患者采取的不同用药方案为组别依据,将其分为采取阿司匹林+氯吡格雷的对照组、采取阿司匹林+替格瑞洛的研究组,每组25例。组间对比治疗效果、不良反应率以及治疗后的心梗发作次数与发作时间、左心室射血分数、左室舒张末期内径。结果研究组总有效率为96.00%,比对照组的72.00%高;研究组不良反应总发生率仅4.00%,比对照组的28.00%低,差异有统计学意义(χ2=5.357,P=0.021<0.05)。治疗后,研究组的心梗发作次数与发作时间均比对照组少或短,左心室射血分数比对照组高,左室舒张末期内径比对照组小,差异有统计学意义(P<0.05)。结论替格瑞洛加阿司匹林对急性心肌梗死有显著疗效及安全性,为患者应用可减少或缩短心梗发作次数与发作时间,改善患者的心功能状况。

Objective To observe the combined treatment effect of ticagrelor and aspirin on acute myocardial infarction Methods A selection of 50 patients who were diagnosed with acute myocardial infarction in the hospital from January 2018 to December 2019 were selected,and their basic data were retrospectively analyzed.The different medication regimens adopted by the patients were used as the grouping basis,they were divided into a control group taking aspirin+clopidogrel and a study group taking aspirin+ticagrelor,each with 25 cases.The treatment effect,adverse reaction rate,number and time of myocardial infarction after treatment,left ventricular ejection fraction,and left ventricular end-diastolic diameter were compared between groups.Results The total effective rate in the study group was 96.00%,which was higher than 72.00%in the control group;the total incidence of adverse reaction rate in the study group was only 4.00%,which was lower than 28.00%in the control group.The differences were statistically significant(χ2=5.357,P=0.021<0.05).After treatment,the number and duration of myocardial infarction in the study group were less or shorter than the control group,the left ventricular ejection fraction was higher than the control group,and the diameter of the left ventricular end-diastolic phase was smaller than the control group,the differences were statistically significant(P<0.05).Conclusion Tigrelor plus aspirin has a significant effect and safety on acute myocardial infarction.It can reduce or shorten the number and duration of attacks and improve the heart function of patients.