托吡酯联合硫必利、氟哌啶醇治疗抽动障碍伴临床下放电患儿的疗效分析

Analysis on Efficacy of Topiramate Combined with Tiapride and Haloperidol in the Treatment of Children with Tic Disorder Complicated with Clinical Discharge

目的分析托吡酯联合硫必利、氟哌啶醇治疗抽动障碍伴临床下放电患儿的临床效果。方法选取2016年12月至2019年12月我院收治的抽动障碍伴临床下放电患儿60例,随机分为观察组(n=30)和对照组(n=30)。对照组采用硫必利联合氟哌啶醇治疗,观察组在对照组基础上采用托吡酯治疗。比较两组的临床疗效。结果观察组的治疗总有效率、脑电图改善率分别为93.33%、 70.00%,明显高于对照组的73.33%、 43.33%(P <0.05)。治疗后,观察组的血浆Glu、 Asp水平均低于对照组(P<0.05)。两组的不良反应发生率(13.33%vs. 6.67%)比较差异无统计学意义(P>0.05)。结论托吡酯联合硫必利、氟哌啶醇治疗抽动障碍伴临床下放电患儿的临床效果显著,可有效缓解其痫性放电,下调其神经兴奋性氨基酸水平,且安全性较高。

Objective To analyze the clinical effect of topiramate combined with thiopiride and haloperidol in the treatment of children with tic disorder complicated with clinical discharge.Methods 60 children with tic disorder complicated with clinical discharge admitted to our hospital from December 2016 to December 2019 were selected and randomly divided into observation group(n=30)and control group(n=30).The control group was treated with tiapride combined with haloperidol,and the observation group was treated with topiramate on the basis of the control group.The clinical efficacy of the two groups was compared.Results The total effective rate of treatment and EEG improvement rate in the observation group were respectively 93.33%and 70.00%,significantly higher than 73.33%and 43.33%in the control group(P<0.05).After treatment,the plasma Glu and Asp levels of the observation group were lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions(13.33%vs.6.67%)between the two groups(P>0.05).Conclusions Topiramate combined with thiopiride and haloperidol has significant clinical effect in the treatment of children with tic disorder complicated with clinical discharge,which can effectively relieve the epilepsy discharge,and lower the nerve excitatory amino acid levels,with higher safety.