摘要
二维纳米材料在电子学、催化、超级电容器和能源材料等领域展现出了巨大的应用潜力.在生物医学领域,以二维超薄纳米材料为代表的低维材料,因其优异的机械、光热、电子和光学性能,以及良好的生物相容性和生物降解性,被广泛用于构建多功能纳米平台并应用于肿瘤的诊疗.本综述概述了石墨炔、黑磷、过渡金属二卤化物、锑烯等新型低维材料的特定结构与性质,详细总结了基于各类对近红外或超声敏感的材料构建的纳米平台在光热、光动力和声动力无创肿瘤治疗中的最新进展,并进一步探讨了纳米材料在无创式癌症治疗中所面临的挑战与应用前景.
In recent years,the emerging two-dimensional(2 D)nanomaterials have shown great potential for a variety of applications such as electronics,catalysis,supercapacitors,and energy materials.In the biomedical arena,these nanomaterials,especially 2 D-ultrathin nanomaterials,have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment,owing to their remarkable mechanical,photothermal,and optical properties.In this review,we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2 D-materials,representatively such as graphdiyne(GDY),black phosphorus,transition metal dichalcogenides(TMDs),and antimonene,for non-invasive cancer therapeutics including photothermal,photodynamic and sonodynamic approaches.The general properties of these 2 D nanomaterials linking to biomedical interests are first introduced,followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments.We also outline the current challenges and prospects of the 2 D materials for non-invasive approaches to cancer treatments in the future.
作者
杨微
吕庆华
赵军
曹励琪
郝轶
张晗
Wei Yang;Qinghua Lyu;Jun Zhao;Liqi Cao;Yi Hao;Han Zhang(Department of Ultrasound,Shenzhen Hospital,Southern Medical University,Shenzhen 518100,China;Institute of Microscale Optoelectronics,Collaborative Innovation Centre for Optoelectronic Science&Technology,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology,Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ),College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China;School of Ophthalmology&Optometry Affiliated to Shenzhen University,Shenzhen 518040,China;Shenzhen Eye Institute,Shenzhen Eye Hospital Affiliated to Jinan University,Shenzhen 518040,China)
基金
supported by the State Key Research Development Program of China(2019YFB2203503)
the National Natural Science Foundation of China(61875138,61435010,81972423 and 61961136001)
Science and Technology Innovation Commission of Shenzhen(KQTD2015032416270385,JCYJ20170811093453105,JCYJ20180307164612205,JCYJ20170307144246792,GJHZ20180928160209731 and 202050345)
the Clinical Research Startup Plan of Southern Medical University(LC2016YM018)
Shenzhen Key Laboratory of Viral Oncology(ZDSYS201707311140430)
the Grant of Sanming Medical Project(SM201702)
the Instrumental Analysis Center of Shenzhen University(Xili Campus)。
