肥胖型PCOS患者体内IL-6的表达及意义

Expression and Significance of IL-6 in Obese PCOS Patients

目的了解白介素-6在肥胖型PCOS患者胰岛素抵抗产生中的作用及意义。方法便利选取2017年8月—2018年7月江苏省扬州大学附属苏北人民医院、南京鼓楼医院集团仪征医院内分泌门诊收治的育龄肥胖PCOS患者30例为肥胖PCOS组,以同期正常体重的育龄妇女30名为对照组,通过自动生化仪测定其糖耐量试验中空腹血糖及胰岛素、餐后2 h血糖及胰岛素,计算胰岛素抵抗指数和胰岛素敏感指数;通过ELISA试剂盒检测研究对象IL-6水平,分析IL-6与BMI、胰岛素抵抗的相关性。结果对照组患者空腹血糖(4.85±0.06)mmol/L、餐后2 h血糖(7.11±0.06)mmol/L、空腹胰岛素(5.11±0.15)μIU/mL、餐后2 h胰岛素(14.09±0.39)μIU/mL、胰岛素抵抗指数(1.10±0.03)、胰岛素敏感指数(27.15±0.74)及白介素-6 (5.88±0.46)pg/mL,优于肥胖PCOS组(t=2.325、4.253、5.214、3.215、6.541、4.652、5.751,P<0.05)。IL-6而与BMI、胰岛素抵抗存在显著正相关性(P<0.05)。结论①肥胖PCOS患者存在严重的糖代谢问题,血糖明显增高,普遍出现高胰岛素血症,同时胰岛素敏感性降低,胰岛素抵抗指数明显升高;②肥胖PCOS患者IL-6含量明显上升,与胰岛素抵抗呈现正相关,可能是通过炎症介导PCOS的发生,进一步引起肥胖。

Objective To understand the role and significance of interleukin-6 in the production of insulin resistance in obese PCOS patients.Methods From August 2017 to July 2018,30 obese PCOS patients of childbearing age at the Endocrinology Clinic of the Subei People’s Hospital Affilated to Jiangsu Yangzhou University and Yizheng Hospital of Nanjing Gulou Hospital Group were selected as the obese PCOS group,and women of childbearing age with normal weight during the same period were selected.30 cases were a control group.The fasting blood glucose and insulin in the glucose tolerance test,the blood glucose and insulin 2 h after a meal were measured by an automatic biochemical instrument,and the insulin resistance index and insulin sensitivity index were calculated;the IL-6 level of the subjects was detected by ELISA kit,Analyze the correlation between IL-6 and BMI and insulin resistance.Results In the control group,fasting blood glucose(4.85±0.06)mmol/L,2 h postprandial blood glucose(7.11±0.06)mmol/L,fasting insulin(5.11±0.15)μIU/mL,2 h postprandial insulin(14.09±0.39)μIU/L mL,insulin resistance index(1.10±0.03),insulin sensitivity index(27.15±0.74)and interleukin-6(5.88±0.46)pg/mL,which were better than the obese PCOS group(t=2.325,4.253,5.214,3.215,6.541,4.652,5.751,P<0.05).IL-6 has a significant positive correlation with BMI and insulin resistance(P<0.05).Conclusion 1.Obese PCOS patients have serious glucose metabolism problems,blood sugar is significantly increased,hyperinsulinemia is common,and insulin sensitivity is reduced,and the insulin resistance index is significantly increased;2.The content of IL-6 in obese PCOS patients is significantly increased,which is associated with insulin resistance It is positively correlated,possibly through inflammation-mediated PCOS,which further causes obesity.