对肝硬化腹水伴自发性腹膜炎患者采取白蛋白与呋塞米联用的临床意义分析

Clinical significance of albumin combined with furosemide in patients with cirrhosis ascites and spontaneous peritonitis

目的探讨对肝硬化腹水伴自发性腹膜炎患者采取白蛋白(ALB)与呋塞米联用的临床意义。方法 80例肝硬化腹水伴自发性腹膜炎患者,随机分为试验组和对照组,各40例。对照组给予敏感抗生素治疗、保肝和水电解质酸碱平衡调节支持等治疗。试验组在对照组治疗的基础上给予人血ALB注射液与速尿注射液治疗。对比两组患者临床疗效;对比两组患者治疗后谷丙转氨酶(ALT)、总胆红素(TBIL)及血清ALB水平。结果试验组患者临床总有效率为75.0%高于对照组的52.5%,差异具有统计学意义(P<0.05)。试验组患者治疗后ALT、TBIL及血清ALB水平分别为(34.21±4.12)U/L、(30.14±2.64)μmol/L、(36.04±6.02)g/L,均优于对照组的(50.34±5.35)U/L、(41.12±3.31)μmol/L、(30.44±5.52)g/L,差异均具有统计学意义(P<0.05)。结论肝硬化腹水伴自发性腹膜炎患者采取ALB与呋塞米联用治疗的临床效果较好,可以有效改善肝硬化腹水伴自发性腹膜炎患者情况。

Objective To discuss the clinical significance of albumin(ALB)combined with furosemide in patients with cirrhosis ascites and spontaneous peritonitis.Methods A total of 80 patients with cirrhosis ascites and spontaneous peritonitis were randomly divided into experimental group and control group,with 40 cases in each group.The control group received sensitive antibiotics,liver protection and water electrolyte acid-base balance regulation,and the experimental group received ALB injection and furosemide injection on the basis of the control group.The clinical efficacy,alanine aminotransferase(ALT),total bilirubin(TBIL)and serum ALB after treatment were compared between the two groups.Results The total clinical effective rate of the experimental group was 75.0%,which was higher than 52.5%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of ALT,TBIL and serum ALB of the experimental group were(34.21±4.12)U/L,(30.14±2.64)μmol/L and(36.04±6.02)g/L,which were better than(50.34±5.35)U/L,(41.12±3.31)μmol/L and(30.44±5.52)g/L of the control group,and the difference was statistically significant(P<0.05).Conclusion ALB combined with furosemide shows good clinical effect for patients with cirrhosis ascites and spontaneous peritonitis,which can effectively improve the condition of patients with cirrhosis and ascites with spontaneous peritonitis.