唑来膦酸联合膳食干预治疗中老年骨质疏松患者的临床研究

A clinical study of zoledronic acid combined with dietary intervention in the treatment of middle-agedand elderly patients with osteoporosis

目的探讨唑来膦酸联合膳食干预对中老年骨质疏松患者的临床疗效。方法 80例中老年骨质疏松患者,随机分为对照组与试验组,各40例。对照组患者均给予静脉滴注唑来膦酸,试验组患者在对照组基础上予以膳食干预。比较两组患者治疗后3、5、12个月疼痛情况[视觉模拟评分法(VAS)评分],比较两组患者治疗后相关生化指标水平(血肌酐浓度,血尿素氮浓度及血钙浓度)。结果试验组患者治疗后3、5、12个月VAS评分分别为(3.82±0.52)、(3.55±0.59)、(3.01±0.43)分,均少于对照组的(4.11±0.73)、(4.00±0.60)、(3.31±0.53)分,差异具有统计学意义(P<0.05)。试验组患者血肌酐浓度(60.07±4.42)μmol/L、血尿素氮浓度(4.61±0.52)mmol/L、血钙浓度(2.13±0.12)mmol/L,均少于对照组的(62.12±4.38)μmol/L、(4.82±0.41)mmol/L、(2.19±0.13)mmol/L,差异具有统计学意义(P<0.05)。结论对中老年骨质疏松患者来说,采取唑来膦酸联合膳食干预的临床效果较好,可有效改善中老年患者骨质疏松情况,值得推广。

Objective To discuss the clinical efficacy of zoledronic acid combined with dietary intervention in the treatment of middle-aged and elderly patients with osteoporosis.Methods A total of 80 middleaged and elderly patients with osteoporosis were randomly divided into control group and experimental group,with 40 cases in each group.The control group received intravenous infusion of zoledronic acid,and the experimental group received dietary intervention based on the control group.The pain status[visual analogue scale(VAS)score]at 3,5 and 12 months of treatment,relevant biochemical indicators(blood creatinine concentration,blood urea nitrogen concentration and blood calcium concentration)after treatment were compared between the two groups.Results VAS score at 3,5 and 12 months of treatment were(3.82±0.52),(3.55±0.59)and(3.01±0.43)points in the experimental group,which was less than(4.11±0.73),(4.00±0.60)and(3.31±0.53)points of the control group,and the difference was statistically significant(P<0.05).The blood creatinine concentration(60.07±4.42)μmol/L,blood urea nitrogen concentration(4.61±0.52)mmol/L and blood calcium concentration(2.13±0.12)mmol/L in the experimental group were less than(62.12±4.38)μmol/L,(4.82±0.41)mmol/L and(2.19±0.13)mmol/L in the control group,and the difference was statistically significant(P<0.05).Conclusion Zoledronic acid combined with dietary intervention shows good clinical effect in the treatment of middle-aged and elderly patients with osteoporosis,which can effectively improve the osteoporosis condition of middle-aged and elderly patients and is worthy of promotion.