聚集诱导发光紫檀芪衍生物分子的制备及活性研究

Study on the Preparation and Activity of Aggregation Induced Luminescent Pterostilbene Derivatives

运用点击反应将四苯乙烯基乙炔与紫檀芪、叠氮等取代的三嗪分子连接,得到了一种含有四苯基乙烯结构的聚集诱导发光紫檀芪衍生物分子,并进一步研究了分子的毒性及细胞摄取等相关的生物活性和药理学性质.这种低毒的荧光探针分子可直观地观察到药物在细胞内外的移动和释放,为下一步靶向药物分子的设计奠定了良好的基础.

In this paper,tetrastyrylacetylene is linked to pterostilbene and azide substituted triazine by click reaction,and a kind of aggregation induced luminescent pterostilbene derivative molecule containing a tetraphenylethylene structure is obtained.In addition,the toxicity of the molecule as well as the related biological activity and pharmacological properties of cell uptake are further studied.This low toxicity fluorescent probe molecule can directly observe the movement and release of drugs in and out of cells,which lays a good foundation for the design of targeted drug molecules in the next step.