中枢神经系统:胰岛素及其类似物的靶点和应用

Targets of Insulin and Insulin Analogues in Central Nervous System and the Implications for Clinical Application

胰岛素作用于中枢神经系统可发挥对能量、葡萄糖代谢平衡以及认知记忆等的调节作用,而中枢胰岛素作用缺陷可能导致能量代谢失衡、高血糖、肥胖等不良后果。因此,如何加强胰岛素在中枢的作用和纠正中枢胰岛素抵抗将成为代谢性疾病治疗的一个新的研究方向。

Insulin acts on the central nervous system to regulate glucose metabolism,energy homeostasis,cognition and memory etc.Defects of insulin action in the central nervous system may lead to unbalanced energy metabolism,hyperglycemia,obesity and other undesirable consequences.Therefore how to strengthen the role of insulin in the central nervous system and correct central insulin resistance will become a new direction of research in the treatment of metabolic diseases.