盐酸帕罗西汀片与盐酸舍曲林片治疗脑卒中后抑郁的效果对比

Comparison of Paroxetine Hydrochloride Tablets and Sertraline Hydrochloride Tablets in the Treatment of Post-stroke Depression

目的:比较盐酸帕罗西汀片与盐酸曲舍林片治疗脑卒中后抑郁的临床疗效和不良反应。方法:选取98例脑卒中后抑郁患者,随机分为观察组(n=48例,常规治疗+口服盐酸曲舍林片)和对照组(n=48例,常规治疗+口服盐酸帕罗西汀片),比较两组临床疗效和不良反应,并于治疗前后对患者的神经功能、抑郁状态进行评价。结果:观察组的临床疗效为77.08%,明显高于对照组的56.20%(P<0.05)。治疗后,观察组的美国国立卫生研究院脑卒中量表(NIHSS)评分与对照组的评分相比无差异(P>0.05),其汉密尔顿抑郁量表(HAMD)评分均显著低于对照组(P<0.05)。两组不良反应发生率比较,无统计学差异(P>0.05)。结论:对于脑卒中后抑郁患者,口服盐酸曲舍林片治疗效果优于盐酸帕罗西汀片,能明显改善患者的神经功能和抑郁状态,不良反应两者相当。

Objective:To compare the clinical efficacy and adverse reactions of paroxetine hydrochloride tablets and traserin hydrochloride tablets in the treatment of post-stroke depression.Methods:98 patients with post-stroke depression were randomly divided into observation group(n=48 cases,routine treatment+oral traxellin hydrochloride)and control group(n=48 cases,routine treatment+paroxetine hydrochloride tablet)to compare the clinical efficacy and adverse reactions of the two groups,and evaluate the neurologic function and depression status of the patients before and after treatment.Results:The clinical efficacy of the observation group was 77.08%,significantly higher than 56.20%of the control group(P<0.05).After treatment,there was no difference in NIHSS score between the observation group and the control group(P>0.05),and the Hamilton Depression Scale(HAMD)score of the observation group was significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For patients with post-stroke depression,oral traserin hydrochloride tablets is better than paroxetine hydrochloride tablets,which can significantly improve the neurological function and depression state of patients,with similar adverse reactions.