中国女性宫外孕危险因素Meta分析

Meta-analysis on risk factors of ectopic pregnancy in Chinese female

目的探讨中国女性宫外孕的主要危险因素,为宫外孕的防治提供依据。方法计算机检索中国知网期刊全文数据库、万方数据库与维普中文科技期刊全文数据库中2008年1月1日至2019年12月31日国内已发表的关于宫外孕致病因素的临床研究文献,进行回顾性分析。对纳入文献进行严格筛选及统计后,采用RevMan 5.3软件进行Meta分析。结果最终纳入11个研究,共2890例患者。Meta分析结果显示,流产、腹部手术史、妇科炎症、性传播疾病、紧急避孕药、使用宫内节育器(IUD)和不良生活方式的合并OR值(95%CI)分别为2.62(2.17~3.17)、1.77(1.43~2.19)、2.34(1.95~2.79)、6.66(3.10~14.34)、2.29(1.68~3.13)、1.79(1.46~2.20)和3.44(2.19~5.39)。结论流产、腹部手术史、妇科炎症、性传播疾病、紧急避孕药、使用IUD、不良生活方式是中国女性发生宫外孕的主要危险因素。

Objective To explore the main risk factors of ectopic pregnancy in Chinese women,and to provide evidence for the prevention and treatment of ectopic pregnancy.Methods A retrospective analysis of 2890 clinical studies on the risk factors of ectopic pregnancy from January 1,2008 to December 31,2019 was conducted by computer retrieval from full-text database of CNKI,Wanfang and VIP Chinese science and technology journals.After rigorous screening and statistics of the included literature,RevMan 5.3 software was used for Meta analysis.Results Eleven studies with a total of 2890 patients were eventually included.The Meta analysis results showed that the pooled odds radio values(95%CI)of abortion,history of abdominal surgery,gynecological inflammation,sexually transmitted diseases,emergency contraception,intrauterine device(IUD)and adverse lifestyle were 2.62(2.17~3.17),1.77(1.43~2.19),2.34(1.95~2.79),6.66(3.10~14.34),2.29(1.68~3.13),1.79(1.46~2.20)and 3.44(2.19~5.39),respectively.Conclusions Abortion,history of abdominal surgery,gynecological inflammation,sexually transmitted diseases,emergency contraception,IUD,and unhealthy lifestyle are the main risk factors for ectopic pregnancy in Chinese women.