萝卜硫素在乳腺癌、卵巢癌及宫颈癌中的潜在作用

The potential role of sulforaphane in breast cancer,ovarian cancer and cervical cancer

随着医学对硫代葡萄糖苷在植物中积累的遗传和环境因素的了解以及对这些化合物及其衍生物作用认识的增加,人们对硫代葡萄糖苷及其产物可能的作用研究也有了重大进展,作为饮食的一部分时,其可以降低肿瘤和心脏病的风险。研究发现,这些生物活性物质与传统的抗肿瘤治疗方法结合起来,可以提高抗肿瘤治疗的效果。萝卜硫素是一种同源异硫氰酸酯,主要存在于芸薹属蔬菜中,其摄入与乳腺癌、卵巢癌等肿瘤的发生呈显著负相关,可能是通过提高细胞的解毒能力和抗氧化能力外,萝卜硫素还可以调节细胞的生长,这对于肿瘤预防尤其重要。萝卜硫素的细胞抑制和细胞毒性作用机制包括诱导细胞凋亡、抑制细胞周期进程和抑制血管生成,靶向肿瘤细胞关键细胞信号通路的多个位点,发挥类似靶向药物的抗肿瘤作用。本篇综述通过介绍萝卜硫素在乳腺癌、卵巢癌及宫颈癌辅助化疗和放疗疗效的可能机制,为其在乳腺癌、卵巢癌及宫颈癌临床上的应用提供理论线索。

As our understanding of the genetic and environmental factors that glucosinolates accumulate in plants and the effects of these compounds and their derivatives has increased,so has our understanding of the role glucosinolates and their products may play in reducing the risk of cancer and heart disease when consumed as part of a diet.After absorption and distribution in the body,they will affect the general defensive mechanisms of the body,including the prevention and treatment of tumors.It has been found that the combination of these bioactive substances with traditional anti-tumor therapies can improve the effectiveness of anti-tumor therapy.Sulforaphane is a homologous isothiocyanate mainly found in brassica vegetables.Evidence shows that the intake of sulforaphane is significantly negatively correlated with cancers such as breast cancer and ovarian cancer.It may be that sulforaphane can regulate cell growth in addition to improving the detoxification and antioxidant capacity of cells,which is particularly important for cancer prevention.The mechanism of cell inhibition and cytotoxicity of sulforaphane includes induction of cell apoptosis,inhibition of cell cycle progression and inhibition of angiogenesis,targeting multiple sites of key cell signaling pathways of tumor cells,and playing an anti-tumor effect similar to that of targeted drugs.This review introduces the possible mechanism of sulforaphane in clinical adjuvant chemotherapy and radiotherapy for breast cancer,ovarian and cervical cancer,and provides theoretical clues for its clinical application in breast cancer and ovarian and cervical cancer.