低聚肽强化麦芽糊精果糖液对胃癌患者临床效果的影响

The effect of oligopeptide-enhanced maltodextrin fructose solution on accelerated rehabilitation surgery in gastric cancer patients

目的探讨低聚肽强化麦芽糊精果糖液对胃癌患者加速康复外科临床效果的影响。方法应用随机数字表法将2017年10月至2019年12月在南京医科大学附属淮安第一医院行胃癌根治术的110例胃癌患者随机分为对照组和联合组,各55例。对照组患者给予常规饮食指导和综合干预措施;联合组患者在对照组基础上术前及术后加服12.5%麦芽糊精果糖饮品及鸡蛋膜活性肽。观察两组患者术后康复效果。结果联合组患者术中补液总量较对照组明显减少,术后首次通气时间、术后排便时间、术后住院时间和住院总费用较对照组明显缩短和减少(P<0.05)。联合组术后7d的白蛋白、总蛋白、前白蛋白和血红蛋白水平相比对照组均明显升高(P<0.05)。术前两组患者的欧洲癌症研究与治疗组织(EORTC)生活质量核心问卷调查(QLQ-C30)评分比较差异无统计学意义(P>0.05),术后除认知功能领域外联合组的EORTC QLQ-C30其他各项目评分与对照组比较差异均有统计学意义(P<0.05)。结论常规加速康复外科杂志联合低聚肽强化干预能增加行胃癌根治术患者空腹状态下的能量及氮储备,改善其围术期主观感受和短期营养状况,有利于患者术后的快速康复和生活质量的提高。

Objective To investigate the effect of oligopeptide strengthening maltodextrin fructose solution on the clinical effect of accelerated rehabilitation surgery in gastric cancer patients.Methods Using the random number table method,110 patients with gastric cancer who underwent radical gastric cancer surgery at the Affiliated Huai'an NO.1 People's Hospital of Nanjing Medical University from October 2017 to December 2019 were randomly divided into a control group and a combined group,with 55 cases in each group.The patients in the control group were given routine diet instruction and comprehensive intervention,the patients in the combined group were given 12.5%maltodextrin fructose drinks and egg membrane active peptide during the perioperative period based on the control group.The postoperative rehabilitation effect between the two groups were compared.Results Compared with the control group,the total amount of intraoperative fluid infusion in the combined group was significantly reduced,and the first ventilation time,defecation time,intravenous infusion time,hospitalization time and total hospitalization cost were significantly reduced(P<0.05).The levels of albumin,total protein,prealbumin and hemoglobin in the combined group were significantly higher than those in the control group(P<0.05).The incidence of postoperative infection in the combined group was lower than that in the control group,but the difference was not statistically significant(P>0.05).There were significant differences in the quality of life core 30 questionnaire(QLQ-C30)score of European Organization for research and treatment of cancer(EORTC)scores between the combined group and the control group after operation,except in the field of cognitive function(P<0.05).Conclusion ERAS combined with oligopeptide-enhanced intervention can increase the energy and nitrogen reserve of patients under the condition of fasting,it can further promote their subjective feelings during the perioperative period and nutritional status in the near future,which is conducive to the overall rapid recovery and improvement of quality of life.