慢性血栓栓塞性肺动脉高压的治疗

Treatment of chronic thromboembolic pulmonary hypertension

慢性血栓栓塞性肺动脉高压(chronic thromboembolic pulmonary hypertension,CTEPH)是肺动脉的急性血栓没有溶解,从而转化为不溶性纤维血栓阻塞近端动脉,合并部分小动脉出现血管病变,近端和远端小血管阻塞而增加肺血管阻力,导致进行性肺动脉高压,从而引起右心动能衰竭直至死亡,是肺血栓栓塞症的一种特殊类型,也是肺动脉高压的常见类型。CTEPH目前的主要疗法包括肺动脉血栓内膜剥脱术(pulmonary endarterectomy,PEA)、药物治疗、介入治疗等。

Chronic thromboembolic pulmonary hypertension(CTEPH)is an acute thrombosis of the pulmonary artery that has not been dissolved,which turns into insoluble fibrous thrombosis to block the proximal artery,combined with vascular disease in some small arteries,and blockage of proximal and distal small vessels,increasing pulmonary vascular resistance leads to progressive pulmonary hypertension,which can cause right heart motility failure even death.It is a special type of pulmonary thromboembolism and a common type of pulmonary hypertension.The current main treatments of CTEPH include pulmonary endarterectomy(PEA),drug therapy,and interventional therapy.