甲钴胺联合叶酸、维生素B6对急性缺血性脑卒中患者血清同型半胱氨酸水平影响的研究

Effects of mecobalamin tablets combined with folic acid tablets and vitamin B6 tablets on serum homocysteine in patients with acute ischemic stroke

目的:分析甲钴胺联合叶酸、维生素B6对伴有高同型半胱氨酸血症(HHcy)的急性缺血性脑卒中患者血清同型半胱氨酸(Hcy)水平的影响。方法:2019年1-12月收治伴HHcy的急性缺血性脑卒中患者150例,随机分为两组,各75例。对照组采用维生素B6片、叶酸片治疗;观察组在对照组治疗的基础上联合甲钴胺片治疗。比较两组治疗效果及对Hcy水平的影响。结果:观察组治疗后Hcy水平显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:对伴HHcy的急性缺血性脑卒中患者实施甲钴胺片联合叶酸片、维生素B6片治疗可有效提高临床疗效,降低Hcy水平。

Objective:To analyze the effect of mecobalamin tablets combined with folic acid tablets and vitamin B6 tablets on the level of serum homocysteine(Hcy)in acute ischemic stroke patients with hyperhomocysteinemia.Methods:From January to December 2019,150 patients with acute ischemic stroke with hyperhomocysteinemia were selected,they were randomly divided into the two groups with 75 cases in each group.The control group was treated with vitamin B6 tablets and folic acid tablets.The observation group was treated with mecobalamin tablets on the basis of vitamin B6 tablets and folic acid tablets.The therapeutic effect and the effect on the level of serum homocysteine were compared between the two groups.Results:After treatment,the level of Hcy in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion:Mecobalamin tablets combined with folic acid tablets and vitamin B6 tablets can effectively improve the therapeutic effect and reduce the level of serum homocysteine in acute ischemic stroke patients with hyperhomocysteinemia.