双重血浆置换治疗抗NMDAR脑炎疗效分析

目的探讨双重血浆置换(DFPP)治疗抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的临床疗效及安全性。方法回顾性分析2019年4月至12月收治的10例抗NMDAR脑炎患者DFPP治疗的临床疗效及不良反应。结果10例患者接受DFPP治疗48次,治疗后临床好转,血清抗NMDAR抗体滴度均有减低成转为阴性。DFPP的不良反应有:管路凝血1例次,低血压1例次,无致死的严重不良反应。结论DFPP可有效治疗抗NMDAR脑炎,临床安全可行。

Objective To explore the clinical eficacy and safey of double fltration plasmapheresis in the treatment of anti-N-methy1-D-aspartate receptor encephalitis.Method The clinical fficacy and adverse reactions of DFPP in 10 patients with NMDAR encephalitis from April to December 2019 were analyzed rtrspecively.Results Ten patients were treated with DFPP for 48 times.All patients(100%)improved after DFPP treatment.The titer of serum anti NMDAR antibody decreased or turned negative.The adverse reactions of DFPP were as follows:1 case of clotting by pipeline,1 case of hipotension,and no serious adverse reactions.Conclusion DFPP can fectively treat anti NMDAR encephalitis,which is safe and feasible in clinic.