摘要
假体周围感染(PJI)是人工关节置换术后灾难性的并发症,其诊疗一直是关节外科领域的研究热点和难点。目前,PJI的治疗策略包括抗生素治疗、保留假体清创灌洗术、Ⅰ期翻修术、Ⅱ期翻修术、关节融合术、截肢以及生物治疗等。常规治疗不能取得满意的疗效,而生物治疗作为一种新兴的治疗模式,在PJI治疗中具有独特的优势。该文就PJI的危险因素和感染源、诊断和分型,以及治疗策略进行综述,为临床PJI治疗方式的选择提供参考。
Periprosthetic joint infection(PJI)is a catastrophic complication after artificial joint replacement,and its diagnosis and treatment has always been a great challenge in the field of orthopedics.At present,the treatment strategies for PJI include suppressive antibiotic therapy,debridement antibiotics irrigation of the retained,prosthesis,one-stage revision,twostage revision,arthrodesis,amputation,and biotherapy,etc.Conventional treatment can not achieve satisfactory results.As a new treatment mode,biotherapy has unique advantages in PJI treatment.This article reviews the risk factors and the source of infection,diagnosis,classification and treatment strategies of PJI,in order to provide valuable reference for clinical treatment of PJI.
作者
刘鹏
曹国定
常彦峰
李鹏
刘军
李旭升
甄平
Liu Peng;Cao Guo-Ding;Chang Yan-Feng;Li Peng;Liu Jun;Li Xu-Sheng;Zhen Ping(Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Joint Surgery,the 940th Hospital of PLA Joint Logistics Support Force,Lanzhou 730050,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2020年第11期1196-1206,共11页
Medical Journal of Chinese People's Liberation Army
基金
全军后勤课题面上项目(CWH17J009)
全军医学科技青年计划(19QNP047)
甘肃省青年科技基金(18JR3RA410)
甘肃省卫生行业科研计划项目(GSWSKY2018-21)
兰州市人才创新创业项目(2019-RC-65)
中央高校创新团队项目(31920200018)
陕西省自然科学基金(2020JM-339)
甘肃省青年科技基金(1606RJYA300)
甘肃省自然科学基金(18JR3RA403)。
关键词
假体周围感染
清创术
Ⅰ期翻修
Ⅱ期翻修
生物治疗
periprosthetic joint infection
debridement
one-stage revision
two-stage revision
biotherapy
