评价门冬氨酸钾镁与胺碘酮联合治疗慢性心力衰竭并室性心律失常的临床疗效

Evaluation on the clinical efficacy of combination of potassium magnesium aspartate and amiodarone in the treatment of chronic heart failure complicated with ventricular arrhythmia

目的评价门冬氨酸钾镁与胺碘酮联合治疗慢性心力衰竭并室性心律失常的临床疗效。方法98例慢性心力衰竭并室性心律失常患者,采用随机信封法分为研究组和比照组,每组49例。比照组患者采用胺碘酮治疗,研究组患者采用门冬氨酸钾镁和胺碘酮联合治疗。比较两组患者治疗效果以及治疗前后心功能指标(心率、PR间期及QT间期)、血生化指标(血钾、血镁)。结果治疗后,研究组患者的治疗总有效率为97.96%,高于比照组的79.59%,差异具有统计学意义(χ^2=8.295,P=0.004<0.05)。治疗前,两组患者心率、PR间期、QT间期比较差异无统计学意义(P>0.05);治疗后,两组患者的心率、PR间期及QT间期均明显优于治疗前,且研究组优于比照组,差异具有统计学意义(P<0.05)。治疗前,两组患者血钾、血镁水平比较差异无统计学意义(P>0.05);治疗后,两组患者的血钾、血镁水平均高于治疗前,且研究组高于比照组,差异具有统计学意义(P<0.05)。结论门冬氨酸钾镁与胺碘酮联合治疗慢性心力衰竭并室性心律失常效果比较理想,能够有效改善患者的心功能,稳定血生化指标,值得临床推广与应用。

Objective To evaluate the clinical efficacy of combination of potassium magnesium aspartate and amiodarone in the treatment of chronic heart failure complicated with ventricular arrhythmia.Methods A total of 98 patients with chronic heart failure complicated with ventricular arrhythmia were divided into research group and control group according to random envelope method,with 49 cases in each group.The control group was treated with amiodarone,and the research group was treated with combination of potassium magnesium aspartate and amiodarone.The therapeutic effect,cardiac function indexes(heart rate,PR interval and QT interval)and blood biochemical indexes(blood potassium,blood magnesium)before and after treatment were compared between the two groups.Results After treatment,the total treatment effective rate of the research group was 97.96%,which was higher than 79.59%of the control group,and the difference was statistically significant(χ^2=8.295,P=0.004<0.05).Before treatment,there was no statistically significant difference in heart rate,PR interval and QT interval between the two groups(P>0.05).After treatment,heart rate,PR interval and QT interval of the two groups were obviously better than those before treatment,and the research group was better than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood potassium,blood magnesium between the two groups(P>0.05).After treatment,the blood potassium,blood magnesium of the two groups were higher than those before treatment,and the research group was higher than the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of potassium magnesium aspartate and amiodarone has an ideal effect in the treatment of chronic heart failure complicated with ventricular arrhythmia.It can effectively improve the patient’s heart function and stabilize blood biochemical indicators.It is worthy of clinical promotion and application.