肿瘤相关成纤维细胞在肿瘤微环境中免疫调节作用的研究现状

Research status of role of cancer-associated fibroblasts in regulation of immune response in tumor microenvironment

目的介绍肿瘤相关成纤维细胞(CAFs)在肿瘤微环境中免疫调节作用的研究现状。方法对国内外近年来有关CAFs在肿瘤微环境中免疫调节作用研究的相关文献进行综述。结果CAFs是肿瘤微环境中重要的细胞成分,可以分泌多种细胞因子、趋化因子,或通过间接效应与肿瘤微环境中的免疫细胞产生复杂的互相作用,调控免疫细胞的转化、浸润和功能,如调控巨噬细胞M2表型和调节T细胞表型的转化、中性粒细胞浸润、NK细胞的功能活化等,参与肿瘤微环境中抗肿瘤相关免疫抑制,最终导致肿瘤的发生、发展、侵袭、转移及治疗耐药。结论CAFs在肿瘤免疫调节过程中发挥了重要作用,但以其为靶点的靶向治疗还有一些问题需要解决,如特异性的标志物、异质性、关键的信号通路等,能否作为今后肿瘤治疗新的靶点,仍需更多的相关研究来证实。

Objective To introduce the research status of the immunoregulation function of cancer-associated fibroblasts(CAFs)in tumor microenvironment.Method The literatures in recent years on the studies of role of CAFs in the regulation of immune response in the tumor microenvironment were collected and summarized.Results The CAFs played a critical role as the components of the tumor microenvironment.The CAFs could product various growth factors and cytokines that were contributed to the immunoregulation including the polarization of the immune cells and the regulation of the function of immune cells in the tumor microenvironment and eventually resulted in the carcinogenesis,tumor progression,invasion,metastasis and therapy resistance.Conclusion CAFs play a significant role in the immunoregulation in tumor microenvironment,but as a potential target for breast cancer,more studies are still needed to discover the specific markers,heterogeneity,and key signaling pathways.