儿童腺病毒肺炎的病原诊断与抗病毒治疗

Pathogenic diagnosis and antiviral therapy of adenovirus pneumonia in children

人腺病毒是儿童呼吸系统病毒性疾病的常见病原之一。腺病毒感染多见于婴儿和5岁以下儿童,可呈流行性、地方性或散发性。引起腺病毒肺炎的主要血清型包括1、2、3、4、5、7、8、19、21和35型,更严重的肺炎与3、7、14、21和55型有关。重症腺病毒肺炎可危及生命,部分患儿肺部可遗留永久性损伤,如闭塞性细支气管炎等,进而影响患儿的生存质量。因此,早期诊断和合理有效治疗对于改善患儿预后至关重要。现主要就儿童腺病毒肺炎的病原诊断和抗病毒治疗方面进行讨论。

Human adenovirus is one of the common pathogens of respiratory viral diseases in children.Adenoviral infections are epidemic,endemic,or sporadic,commonly detected in infants and children under 5 years old.The main serotypes that cause adenovirus pneumonia include types 1,2,3,4,5,7,8,19,21 and 35.Serotypes 3,7,14,21 and 55 lead to more severe adenovirus pneumonia,which can be fatal and possibly cause permanent damage such as bronchiolitis obliterans to the lungs of some patients,thus affecting the quality of life of patients.Therefore,early diagnosis as well as rational and effective treatment is essential for improving the prognosis of children with adenovirus pneumonia.In this paper,the pathogenic diagnosis and antiviral therapy of adenovirus pneumonia in children were discussed.