儿童腺病毒感染及呼吸系统相关性疾病

Adenovirus infection and respiratory-related diseases in children

腺病毒发现60余年来,人腺病毒感染全球普遍存在,时有局部暴发流行。腺病毒通过基因重组,不断有新基因型被发现,新的基因型其致病特点各异,不同国家或地区之间流行的基因型存在差异。腺病毒感染可引发呼吸系统、胃肠系统、泌尿系统及眼部疾病。儿童腺病毒呼吸道感染发生率高,重症病例多,病死率高。目前,尚无抗病毒药物批准用于腺病毒感染治疗。儿童重症腺病毒肺炎病死率超过50%,是目前重症监护病房重症肺炎救治难题。现综述人腺病毒感染研究进展,并总结儿童腺病毒感染呼吸系统疾病相关研究,以提高对儿童腺病毒感染相关呼吸系统疾病的认识。

Adenovirus(AdV)infection has been prevalent in the world for more than 60 years,with occasional local outbreaks and epidemics.Through gene recombination,new genotypes of AdV have been discovered continuously,showing varying pathogenic characteristics.Genotypes prevalent in different countries or regions are diverse.AdV infection can cause respiratory,gastrointestinal,urinary and eye diseases.The incidence and mortality of AdV respiratory tract infection are high in children,and there are many severe cases.At present,no antiviral drug approved to treat AdV infection.Severe AdV pneumonia in children has a fatality rate exceeding 50%,which becomes a difficult problem in the treatment of severe pneumonia in intensive care unit.This paper reviews the research progress of AdV infection,and summarizes the related research of respiratory system diseases in children with AdV infection,so as to improve the understanding of children with AdV infection related respiratory diseases.