大黄对脑出血急性期患者血清NT-proBNP、Hs-CRP及神经功能的影响

Effect of Rhubarb on Serum NT-proBNP,Hs-CRP and Nerve Function in Patients with Acute Cerebral Hemorrhage

目的探讨大黄治疗脑出血急性期患者的临床疗效。方法选取60例脑出血急性期患者,随机分为观察组和对照组各30例,对照组给予常规治疗加早期康复训练,观察组在对照组基础上给予大黄口服或鼻饲。比较2组治疗总有效率;治疗前及治疗7 d、14 d后血肿体积、神经功能缺损评分(NIHSS)、血清氨基末端脑钠肽前体(NT-proBNP)、血清超敏C反应蛋白(Hs-CRP)浓度、中医症状体征积分及合并症变化。结果观察组治疗总有效率为96.7%,显著高于对照组76.7%(P<0.05);与对照组比较,观察组在治疗前血肿体积、NIHSS、血清NT-proBNP、血清Hs-CRP浓度及中医症状体征积分无统计学差异(P>0.05),观察组治疗7 d及14 d后患者血肿体积明显缩小,神经功能缺损评分、血清NT-proBNP、血清Hs-CRP值、中医症状体征积分显著降低(P<0.05),观察组与对照组总合并症发生率分别为13.3%与36.7%,2组比较有统计学意义(P<0.05)。结论大黄治疗脑出血急性期的临床疗效显著,值得推广应用。

Objective To explore the clinical efficacy of rhubarb in treating acute cerebral hemorrhage. Methods Sixty patients with acute cerebral hemorrhage were selected and randomly divided into observation group and control group,with 30 cases in each group. The control group was given conventional treatment and early rehabilitation training,and the observation group was given rhubarb orally or nasally fed on the basis of the control group. The total treatment efficiency between the two groups,hematoma volume,neurological deficit score( NIHSS),serum N-terminal pro-brain natriuretic peptide( NT-proBNP),serum hypersensitivity before treatment,7 days and 14 days after treatment C reaction,protein( Hs-CRP) concentration,TCM symptoms and signs scores and changes in comorbidities was compared. Results The total effective rate of the observation group was 96. 7%,which was significantly higher than 76. 7% of the control group( P < 0. 05). Compared with the control group,there was no significant difference between the hematoma volume,NIHSS,serum NT-proBNP,serum Hs-CRP concentration of the observation group before treatment and the TCM symptom and sign score( P > 0. 05). In the observation group,on the7 th and 14 th days after treatment,the amount of hematoma was significantly reduced,the neurological deficit score,serum NT-proBNP,serum Hs-CRP value,and TCM symptoms and signs scores were significantly reduced( P < 0. 05). The total incidence of complications in the observation group and the control group was 13. 3% and 36. 7%,respectively. There was statistical significance between the two groups( P < 0. 05). Conclusion Rhubarb has an important clinical treatment effect on acute cerebral hemorrhage and is worthy of popularization and application.