辨证结合西药分期治疗反复发作性尿路感染临床观察

Clinical Observation on Traditional Chinese Medicine Syndrome Differentiation Combined with Western Medicine in the Treatment of Recurrent Urinary Tract Infection by Stages

目的观察中药联合抗生素治疗反复发作性尿路感染的临床疗效。方法将92例反复发作性尿路感染患者随机分为观察组和对照组,观察组48例,对照组44例。急性期观察组予以抗生素联合中药汤剂口服,对照组单纯予以抗生素口服。缓解期观察组中药辨证治疗,对照组长期低剂量抑菌治疗,疗程3个月。比较2组临床疗效、证候疗效、尿感次均发作天数、SAS评分、尿S-IgA。结果在临床疗效、证候疗效、反复发作性尿感次均发作天数、SAS评分、尿S-IgA方面,观察组均优于对照组(P<0.05,P<0.01);观察组随访1年尿感再发次数优于对照组(P<0.05)。结论中药汤剂联合抗生素分期治疗反复发作性尿路感染能显著提高临床疗效,缓解期使用中药辨证治疗,疗效优于长期抗生素抑菌治疗。

Objective To observe the clinical efficacy of Chinese medicine combined with antibiotics in the treatment of recurrent urinary tract infection. Methods 92 patients with recurrent urinary tract infection were randomly divided into observation group and control group,with 48 patients in observation group and 44 patients in control group. In the acute phase,the observation group was treated with antibiotics combined with TCM decoction orally,while the control group was treated with antibiotics orally only. In the remission phase,the observation group was treated with TCM syndrome differentiation,and the control group was treated with long-term low-dose bacteriostatic therapy,with a course of 3 months. The clinical efficacy,syndrome efficacy,average duration of urinary tract infection,SAS score and urinary S-IgA were compared between the two groups. Results The clinical efficacy,syndrome efficacy,the difference in the number of days of recurrent urinary sensation,SAS score and urinary S-IgA in the observation group were all better than those in the control group( P < 0. 05,P <0. 01). After a one-year of following-up,the frequency of recurrent urinary tract infection in the observation group was better than that in the control group( P < 0. 05). Conclusion TCM decoction combined with antibiotics can significantly improve the clinical efficacy of recurrent urinary tract infection. In the remission stage,the curative effect of traditional Chinese medicine syndrome differentiation treatment is better than that of the long-term antibiotic bacteriostatic treatment.