沙美特罗替卡松吸入粉雾剂的临床应用及仿制药研发现状

Clinical application and generic drug development of salmeterol xinafoate and fluticasone propionate powder for inhalation

沙美特罗替卡松吸入粉雾剂是长效β2受体激动剂和糖皮质激素的复方制剂,主要适应症为支气管哮喘和慢性阻塞性肺疾病。近年来由于原研药沙美特罗替卡松吸入粉雾剂的化合物专利和装置专利到期,国内外开展了大量仿制药研发工作。本文重点介绍沙美特罗替卡松吸入粉雾剂在哮喘和慢性阻塞性肺疾病的临床应用和国内外仿制药的研发进展,旨在使国内的读者了解国外用于治疗的新的剂型。

Salmeterol xinafoate and fluticasone propionate powder for inhalation is a long-acting β2 receptor agonist and corticosteroid compound preparation. Its main indications are bronchial asthma and chronic obstructive pulmonary disease(COPD).In recent years, due to the expiration of compound patents and device patents of Sulitide inhaler, a large amount of generic drug research and development has been carried out at home and abroad. This article focuses on the clinical application of Sulitide powder inhaler in asthma, COPD and the development of generic drugs. It aims to help domestic readers to understand the new dosage forms for treatment abroad.