重离子束肿瘤放疗的免疫调节作用和机制研究进展

Advances in immunoregulation and mechanism of heavy ion beam radiotherapy

重离子束肿瘤放疗较常规射线具有显著的放射物理和生物学优势。重离子束在直接杀伤肿瘤细胞的同时,可通过诱导肿瘤细胞免疫原性死亡、调节肿瘤表型、增强抗原提呈、改变肿瘤微环境等调节免疫应答,促进效应T细胞的启动和激活,减少免疫逃逸。本文将对重离子束肿瘤放疗的免疫调节作用及联合免疫检查点抑制剂治疗的相关分子机制进行综述。

Heavy ion radiation has significant radiological and biological advantages over conventional radiation.While directly killing tumor cells,heavy ion beam can reduce immune escape and promote the initiation and activation of effector T cells by inducing immunogenic death of tumor cells,regulating tumor phenotype,enhancing antigen formulation,and changing tumor microenvironment to regulate the immune response.This article will review the immunomodulatory effect of heavy ion beam and the molecular mechanisms associated with immune checkpoint inhibitor therapy.