摘要
The utility of placental growth factor(PIGF)and its receptor VEGFR-1(Flt-1)as biomarkers for cervical cancer has not been clarified yet.To address this issue,we investigated the levels of soluble PIGF(sPIGF)and soluble Flt-1(sFlt-1)in the serum from patients with early cervical cancer,cervical intraepithelial neoplasia(CIN)and controls in this study.sPIGF and sFlt-1 were detected in 44 preoperative patients with cervical cancer,18 cases with CIN,and 20 controls by ELISA.It was found that both sPIGF and sFlt-1 were significantly increased in the cervical cancer group as compared with those in CIN and control groups.sPIGF presented a high diagnostic ability of cervical cancer,with a sensitivity of 61.36%and a specifcity of 89.47%;and sFlt-1 with a sensitivity of 50.00%and a specifcity of 92.I 1%。Importantly,the combined use of sPIGF and sFlt-1 could increase the diagnostic rate of cervical cancer,with a sensitivity of 70.45%and a specificity of 92.11%.These results indicated that both sPIGF and sFlt-1 in circulation can serve as possible valuable diagnostic biomarkers for cervical cancer,and the combined use of them can be more valuable to diagnose the patients with early cervical cancer.
基金
This work was supported by the National Natural Science Foundation of China(No.81202063).
