丁苯酞用于慢性脑供血不足治疗中的效果观察

Observation of the Effect of Butylphthalide in the Treatment of Chronic Cerebral Insufficiency

目的:探讨慢性脑供血不足治疗中运用丁苯酞的效果。方法:将神经内科80例慢性脑供血不足患者(2017年1月~2019年3月间)纳入研究,用计算机随机分为常规组和干预组各40例,对常规组实施阿司匹林+丹参片+氟桂利嗪治疗,对干预组另实施丁苯酞治疗,分析两组患者疗效、炎症指标、脑血流、用药不良反应状况。结果:干预组总有效率与常规组组间对比更高,干预组治疗后血清C反应蛋白水平与常规组组间对比更低,干预组治疗后基底动脉和椎动脉血流速度与常规组组间对比更高,差异显著(P<0.05);干预组不良反应总发生率5.0%与常规组7.5%组间对比无明显差异(P>0.05)。结论:慢性脑供血不足治疗中运用丁苯酞可提升炎症控制效果,改善脑血流,并提升治疗效果,且不增加用药不良反应。

Objective:To investigate the effect of butylphthalide in the treatment of chronic cerebral insufficiency.Methods:80 patients with chronic cerebral insufficiency(January 2017 to March 2019)were selected and divided into conventional group(n=40)and intervention group(n=40)using the computer random grouping.The conventional group was given aspirin combined with flunarizine therapy,and the intervention group was given butyphthalide treatment,then the curative effect,inflammation index,cerebral blood flow,and the incidence of adverse reactions were analyzed.Results:The total efficiency of the intervention group was higher than that of the conventional group,compared with the conventional group,the serum C reactive protein level was lower in the intervention group,and the blood flow velocity of basilar artery and vertebral artery in the intervention group were higher than those in the conventional group,with significant difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the conventional group(7.5%)and intervention group(5%)(P>0.05).Conclusion:The use of butylphthalide in the treatment of chronic cerebral insufficiency can improve the effect of inflammation control,improve the cerebral blood flow,and improve the therapeutic effect without increasing the adverse drug reactions.