lncRNA调控自噬在老年性痴呆中的研究概况

Advances in the Study of LncRNA in Alzheimer's Disease

老年性痴呆因发病机制及影响因素复杂,在国内人口老龄化趋势、老年结构比例明显上升,以阿尔茨海默病(AD)所占60%~80%比例为主,严重影响人们生活水平的质量。长链非编码RNA(long non-coding RNA,lncRNA)在疾病的发生、发展和生物体的生长、发育以及和细胞自噬的研究中发挥着重要作用。大量的研究表明:lnc RNA与AD患者的相关性以及其在细胞自噬调控中起了重要作用。lncRNA参与miRNA的调控,lncRNA也可能通过miRNA参与疾病的发生发展,可能与细胞自噬水平、以及其他的神经细胞毒性损伤有关联,对学习记忆和认知能力有影响。作者从LncRNA、自噬调控、中医药与AD的研究进展作以下综述。

Senile Dementia is due to the complex pathogenesis and influencing factors,the aging trend of the population in China is obvious,and the proportion of elderly structure is gradually increasing,among which Alzheimer's Disease(AD)accounts for about 60%~80%of senile dementia patients.Recently,it has seriously affected people's living standard and quality.Long non-coding RNA(lncRNA)plays an important role in the occurrence and development of diseases,the growth and development of organisms,and the study of Autophagy in Cells.A large number of studies have shown that LNC RNA plays an important role in the regulation of Autophagy in patients with AD.LncRNA is involved in the regulation of miRNA.LncRNA may also be involved in the occurrence and development of disease through miRNA,which may be associated with Autophagy level of cells and other toxic damage of nerve cells,and may have an impact on learning,memory and cognitive ability.The author will summarize the research progress of lncRNA,Autophagy and AD.