小金胶囊联合来曲唑对子宫内膜异位症患者的疗效及血清EMAb水平的影响

Effect of Xiaojin Capsules combined with letrozole on endometriosis and serum EMAb level

目的研究小金胶囊联合来曲唑对子宫内膜异位症(EMs)患者的疗效及血清抗子宫内膜抗体(EMAb)和性激素水平的影响。方法研究对象为收治的128例EMs患者,根据随机数字表法均分为对照组和观察组。对照组采用来曲唑治疗,观察组采用小金胶囊联合来曲唑治疗。比较2组患者治疗后的临床疗效、血清EMAb、性激素水平以及血流变学情况,并分析2组不良反应发生情况以及随访1年的复发率和妊娠率。结果观察组总有效率(93.75%)明显高于对照组(81.25%),P<0.05。治疗后2组患者的促卵泡生成素(FSH)、黄体生成激素(LH)、雌二醇水平(E2)、EMAb和癌胚抗原125(CA125)水平均显著降低,其中观察组治疗后各指标均低于对照组(P<0.05)。治疗后2组患者的血液黏度、血沉水平以及高、低切血液黏度均显著降低,其中观察组治疗后各黏度均低于对照组(P<0.05)。2组患者不良反应主要为恶心、头痛、体质量增加,不良反应发生率比较差异无统计学意义。2组患者随访1年的妊娠率(71.74%vs 50.00%)、复发率(7.81%vs 20.31%)比较差异有统计学意义。结论小金胶囊联合来曲唑治疗EMs效果显著,能显著降低血清EMAb和性激素水平,可改善血液流变学,从而提高妊娠率,降低复发率,有利于预后。

Objective To study the effects of Xiaojin Capsules and letrozole on endometriosis(EMs)and serum anti endometrial antibody(EMAb)and sex hormone levels.Methods 128 patients with EMs were divided into control group and observation group according to random number table averagely.The control group was treated with letrozole,while the observation group was treated with Xiaojin Capsules combined with letrozole.The clinical efficacy,serum EMAb,sex hormone levels and hemorheology of the 2 groups were compared after treatment.The incidence of adverse reactions,and the recurrence rate and pregnancy rate of the 2 groups after 1 year follow-up were also counted.Results The total effective rate of the observation group(93.75%vs 81.25%)was significantly higher than that of the control group(P<0.05).After treatment,the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),EMAb and carcinoembryonic antigen 125(CA125)in the 2 groups were significantly decreased,and the indexes in the observation group were lower than those in the control group(P<0.05).The blood viscosity,erythrocyte sedimentation rate and high and low shear blood viscosity of the 2 groups were significantly decreased after treatment,and the viscosity of the observation group after treatment was lower than that of the control group(P<0.05).The main adverse reactions of the 2 groups were nausea,headache and weight gain.There was no significant difference in the incidence of adverse reactions between the 2 groups,with significant difference in pregnancy rate(71.74%vs 50.00%)and recurrence rate(7.81%vs 20.31%)between the 2 groups after 1 year′s follow-up(P<0.05).Conclusion Xiaojin Capsules combined with letrozole is effective in treating EMs.It can significantly reduce serum EMAb and sex hormone levels and improve hemorheology,thereby increase pregnancy rate and redue recurrence rate,which is conducive to prognosis.