二氮杂环药效团推动先导化合物发现的研究进展

Research progress of diazacyclic pharmacophore promoting the discovery of lead compounds

目的综述二氮杂环类化合物推动先导化合物发现的研究进展,为高效、优质药物的设计提供参考。方法检索国内外相关文献,对二氮杂环类化合物进行归纳和综述,介绍二氮杂环类化合物自身的结构特点、生物活性及其在结构修饰中的应用。结果二氮杂环类化合物(吡嗪、嘧啶和哒嗪)具有独特的结构特征、广泛的生物活性以及丰富的结构修饰物。结论二氮杂环类化合物在药物设计中有着独特的优势,有助于提高并丰富多种结构母体的生物活性,具有广阔的研究和开发前景。

Objective The research progress of diazacyclic compounds promoting the discovery of lead compounds was investigated in order to provide reference for the design of high efficiency and high quality drugs.Methods The related literatures at home and abroad were searched,the diazacyclic compounds were summarized and reviewed,and the characteristics,biological activities and applications of diazacyclics in structural modification were introduced.Results Diazacyclics(pyrazines,pyrimidines and pyridazines)have unique structural characteristics,extensive biological activities and rich structural modifiers.Conclusion Diazacyclic compounds have unique advantages in drug design,help to enhance and enrich the biological activity of various structural precursors,and have broad research and development prospects.