比较3种类型的华法林维持剂量算法对东台地区汉族心房颤动患者国际标准化比值的达标率

Comparison of international normalized ratio compliance rates of the 3 warfarin maintenance dose algorithms for Han Chinese patients with atrial fibrillation in Dongtai area

目的:评价3种不同类型的华法林维持剂量算法对东台地区汉族心房颤动患者国际标准化比值(international normalized ratio,INR)达标率优势。方法:选取312名接受基于华法林治疗方案治疗的房颤患者,按照3种不同类型的华法林维持剂量算法分为Warfarindosing模型组(n=103),IWPC模型组(n=109),医师制定组(n=100)。收集3组患者的一般临床资料,CYP2C9 rs1057910和VKORC1 rs9923231基因多态性检测数据,7 d后INR达标人数和达标率,评价3种华法林维持剂量模型算法对INR达标率的优势。结果:Warfarindosing模型组INR达标率为67.0%,与IWPC模型组(45.0%)和医师制定组(31%)相比,达标率显著提升,差异具有统计学意义(P<0.05)。结论:Warfarindosing模型算法更适用于东台地区汉族房颤患者,显著提高患者INR达标率。但仍需进一步加大样本量研究。

Objective:To evaluate the advantages of three different types of warfarin maintenance dose algorithms for the international normalized ratio(INR)compliance rate of Han Chinese patients with atrial fibrillation in Dongtai area.Methods:A total of 312 patients with atrial fibrillation who were treated with warfarin-based regimens were enrolled in groups according to three different types of warfarin maintenance dose algorithms:103 in the Warfarindosing model group and 109 in the IWPC model group.In 100 patients,the clinical general data of three patients,CYP2C9 rs1057910 and VKORC1 rs9923231 gene polymorphism data were collected.After 7 days,the number of INR targets and the compliance rate were evaluated.Three warfarin maintenance dose model algorithms were evaluated for INR compliance rate.Results:The INR compliance rate of the Warfarindosing model group was 67.0%,which achieved a significant improvement when compared with the IWPC model group(45.0%),and the physician-defined group(31%),the difference was statistically significant(P<0.05).Conclusion:The Warfarindosing model algorithm is more suitable for patients with atrial fibrillation in Hantai,Dongtai area,and significantly improves the INR compliance rate.However,further research on sample size is still needed.