糖尿病肾病肾小管病变的研究进展

Research progress in renal tubular lesions in diabetic nephropathy

糖尿病肾病(diabetic nephropathy,DN)是糖尿病重要的并发症。DN的发病机制复杂,以往认为病变主要集中在肾小球,最近研究发现肾小管损伤在DN中发挥了重要作用。肾小管病变甚至要早于肾小球,其损伤程度与DN患者的肾功能进展及预后密切相关。因此,早期发现肾小管损伤具有重要的临床意义。

Diabetic nephropathy(DN)is an important complications of diabetes mellitus.The pathogenesis of DN is complex.In the past,it was thought that the lesions were mainly concentrated in the glomeruli.Recent studies have found that renal tubular injury plays an important role in DN.Renal tubular lesions are even earlier than glomeruli.The degree of injury is closely related to the progress and prognosis of renal function in DN patients.Therefore,early detection of renal tubule injury is of great clinical significance.